Laboratory Research Scientist - ARSENAL Liquid Biopsy Platform
The Francis Crick Institute
The Applied Biotechnology Laboratory, led by Group Leader Samuel Rodriques, works at the interface between academic bioengineering and biotechnology entrepreneurship. Our goal is to develop biotechnologies that address major unmet needs in biology and medicine and to put them into every laboratory or every clinic in the world.
In order to develop therapeutics to treat neurodegenerative diseases, such as Alzheimer’s, it is necessary to diagnose those diseases long before the onset of symptoms. Various small molecules, nucleic acids, or proteins may facilitate the early detection of neurodegenerative diseases from the blood, but these biomarkers are often at very low concentration because they do not efficiently cross the blood-brain barrier. We are developing ARSENAL, a liquid biopsy technology that utilizes DNA nanotechnology to quantify microRNAs, circRNAs, proteins, and other circulating disease-linked factors with ultrahigh sensitivity in blood samples.
This position is for a fixed term candidate to lead the development of the ARSENAL technology. The candidate will use a variety of nucleic-acid-based and biophysical technologies, such as next-generation sequencing, qPCR, surface plasmon resonance biolayer interferometry, etc., to conduct basic proof of concept experiments, quantify and optimize the sensitivity and specificity of ARSENAL, and then to apply ARSENAL to clinical samples.
The postholder’s key responsibilities include, but are not limited to:
Independently conducting experiments and analyzing results related to the ARSENAL technology. Pursuing collaborations with other academic labs to apply the ARSENAL technology to different systems. Maintaining high-quality lab notes and maintaining the central lab inventory. Reporting on a regular basis to the leader of the Applied Biotechnology Laboratory Presenting results at lab meetings and at international conferences. Writing up results and publishing papers in major, internationally recognized journals. Assisting in training other members of the laboratory.
Key experience and competencies
The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:
Higher education degree in bioengineering, molecular biology or similar
At least 1 years’ experience with biotechnology development
Experience with next-generation sequencing, qPCR/rtPCR, and the design of DNA libraries/nanotechnology
Strong skills in organising and thorough record-keeping
Strong collaborative ability and teamwork experience
Experience with biophysical methods, such as surface plasmon resonance or biolayer interferometry.
Experience with programming, especially in python