The long-term objective of our team in this project area is to develop intelligent bio-nano sensors and nanodevices for various medical and nanotechnological applications. Our approach is a step-wise one that initially envisions the use of various biomolecular elements (e.g. peptides, DNA strands, etc.) - that are capable of generating motion, exerting force, or producing a signal- as fundamental machine components. These components will be designed to perform different functions in response to specific physiochemical stimuli in a variety of native and non-native settings. In this manner, these individual biomolecular elements will serve as sensors, actuators, transmission elements or modulating agents. By assembling different components together in the proper proportion and orientation, we will generate nanodevices with multiple degrees of freedom, able to apply forces and manipulate objects. Eventually, these devices will be evolved into robotic machines that are able to autonomously perform complex tasks. Nanorobotic devices will be a boon to the biomedical research, therapeutics, and diagnostics arenas, as these devices offer the promise to manipulate single cells, to deliver small amounts of material at precise locations, to detect target agents even at a low nanomolar concentrations level and, in general, to do useful physical work on the molecular level. Such bionanorobotic devices will hopefully be the basis of an arsenal of future medical and nanotech devices that will automatically perform operations, inspections and treatments while achieving ultra-high accuracy in time and space.