Microscopy, Bionano, Nanopathologies

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Nanodiagnostics

Italy

The main technical instrument used by Nanodiagnostics is an Environmental Scanning Electron Microscope (ESEM) equipped for the purpose. Applying their own protocols to be adapted to any type of observation, the Laboratory examines biological samples, including living cells, without affecting their integrity, and can repeat the observation whenever it is wanted. The main objective of the investigation, the identification of inorganic micro- and nano-particulate possibly contained in the sample studied, is achieved without any processing of the sample, so that it remains intact. An EDS (Energy Dispersive Spectroscopy)microanalysis completes the study measuring the characteristic energy that each element composing the particles sends back to the instrument as X-rays when they are hit by the electron beam emitted by the instrument. That way the spectroscope shows the elemental composition of the particle observed. So, combining observation and analysis, it is possible to identify, photograph, measure and characterize by chemical composition, shape and size the micro- and nanoparticles that are possibly present in the sample. All that is done in a non-invasive, non-destructive and repeatable way with the sole exception of fluids that are often impossible to recover. The investigation can be carried out on specimens of biological origin like biopsies, autopsies, organic fluids or food. But it can be done also on a great variety of matrices: environmental samples, drugs, cosmetics, industrial products treated with or polluted by particles.