Safe-by-Design assessment for military clothing and equipment. ML-based prediction of chemical properties and skin exposure modeling for protective garments. SbD4Skin Chemical Safety Toxicity Modeling Our Safe-by-Design (SbD) framework for military clothing applies ML-based prediction of chemical properties to assess the safety of materials used in protective garments before they reach personnel. Chemical exposure through skin contact is a critical concern in modern military operations. Using our SbD4Skin platform, we model the interaction between garment materials and the skin, predicting potential dermal absorption rates and toxic thresholds for a wide range of chemical compounds used in military textiles, dyes, and treatments. This approach enables manufacturers and procurement agencies to identify and eliminate hazardous materials during the design phase, long before physical prototyping or field deployment. SbD4Skin Platform Purpose-built tool for safe-by-design assessment of chemicals in contact with skin Toxicity Modeling ML-based prediction of chemical toxicity and dermal absorption for garment materials Skin Exposure Assessment Quantitative modeling of chemical permeation rates and exposure thresholds for military textiles Design-Phase Safety Identify and eliminate hazardous materials before physical prototyping, reducing development risk