Fast-Track Your Extracellular Vesicle Isolation Scale-Up. Sample processing and workflow development for isolating EVs. Obtain Purified EVs Faster. Count on our experienced process development team to isolate your EVs. Avoid Process Development Headaches. Bypass the guesswork involved from the start. Accelerate Your EV Therapeutics R&D. We handle the EV isolation, so you can return to your functional studies sooner. Why Outsource Your EV Isolation? Therapeutics-focused EV researchers often face the challenge of efficiently scaling up EV isolation for large-volume processing. When making the leap to larger starting volumes, it is common to find that the required specialised technology is unfamiliar or inaccessible. Navigating this scale-up process alone can be tough, frustrating and time-consuming. With our expertise though, you can fast-track your EV isolation scale-up and accelerate your overall timelines – allowing you to refocus on therapeutic development sooner. Accelerate Your EV Therapeutic Development. Our bioprocessing team has successfully navigated the intricacies of sample preparation and separation on a large scale – so you don’t have to. We are adept in: EV Isolation: size exclusion chromatography (SEC) and complementary methods including TFF; Building customised SEC columns with access to a range of resins; Bioprocess development guided by high-resolution particle characterisation. Before large-scale testing, you must first scale up isolation workflows to handle bigger volumes. Partnering with an experienced process development team can speed up therapeutic development, reduce costs, and allow you to focus on your unique aspects of development. Leaning on our experience makes scaling up much smoother and means you aren’t left troubleshooting alone. Outsourcing your scale-up to us allows for a more seamless transition through pilot runs and beyond, keeping your development moving forward. What Does Outsourcing EV Sample Processing Involve? Consultation: We discuss your specific situation in detail: sample type, sample volume, long-term goals and specific requests. Send your sample: Ship your sample to our Boston facilities. Protocol development: We next develop and optimise an EV isolation protocol to obtain a purified EV isolate from your sample. EV isolate collection and analysis: We conduct assessments of your purified isolate as agreed on during the consultation step. These are customisable to your sample. Receive your isolate: We send you your isolate and all the associated data. Optional: Tech transfer: We schedule a time to set up an isolation process at your facility. Return to your R&D!: With your purified EV isolate at hand, continue with your good work! What sample types do you work with? The principles of sample preparation and isolation remain the same for most sample types. Therefore, we are open to whatever project you have in mind – just reach out to the team to confirm it will be a good fit. What sample volumes do you work with? In addition to being the leading provider of EV isolation solutions for sample volumes from 150 µL to 100 mL, we have recently processed samples for customers ranging from 1 to 2000 L starting volumes! For those scaling in volume, we have found that the 6-10 L range serves as a practical volume for feasibility studies, where it makes sense to optimise around this range before going much larger. Where can samples be processed? Currently, this service is run from our facilities in Boston and in Lyon. If you are based outside the US or Europe, let us know your requirements to see what we can do. How much does EV isolation process development and sample processing cost? To give you an idea, you can outsource your EV isolation scale-up of ~6-10 L batches for a very competitive cost of ~25K USD. To discuss the cost of tech transfer and for other volume ranges, talk to the team. Can you run any functional studies to assist with therapeutic development? We do not run any functional studies – best if we leave that to you! We do measure the purity and physical characteristics of your EVs, and we can incorporate additional molecular characterisation work – just ask!
