Our team specializes in providing end-to-end in vitro ADME services, covering all key areas—absorption, distribution, metabolism, and excretion. With a wealth of experience, we provide expert guidance throughout the drug discovery journey, spanning from the initial hit identification phase to lead optimization, and ultimately culminating in the identification of clinical candidates. Our in-depth in vitro ADME services are designed to provide valuable insights and data that help address potential issues and enhance the efficiency of your drug development endeavors. Key areas of expertise within our In Vitro ADME services include: Physiochemical Studies: * Kinetic solubility assessments. * Chemical stability evaluations. * Thermodynamic solubility in PBS, SGF, SIF. * Early formulation assessments, and more. In Vitro Metabolism Services: * Metabolite stability studies using liver microsomes, hepatocytes, rCYPs, and S-9 fractions. * Blood/plasma/brain/tissue/microsomal protein binding studies. * CYP phenotyping and CYP induction using PXR cell lines. * GSH (Glutathione) adduct evaluations. In Vitro Permeability and Transporter Studies: * MDCK/Caco-2 permeability assessments. * CYP profiling to understand the involvement of CYP enzymes. * TDI (Therapeutic Dose Index), and more. * Inhibition and substrate evaluations of P-glycoprotein (P-gp) and BCRP (Breast Cancer Resistance Protein) transporters. * CYP (Cytochrome P450) inhibition studies. * Stability assessments in plasma, buffer, blood, and blood/plasma ratio. * PAMPA (Parallel Artificial Membrane Permeability Assay) studies. Our in vitro DMPK scientists deliver high-throughput, reproducible data that help streamline candidate prioritization and predict human pharmacokinetics early in the pipeline.
Compiled from https://www.jubilantbiosys.com
