By 4Spin
The 4Spin ® technology allows to spin hyaluronic acid of both, low molecular weight (LMW) and high molecular weight (HMW), into different structures enabling to produce a wide scale of nanofibrous materials of various properties covering the specific needs of the different applications in the field of wound healing, tissue engineer-ing and drug delivery. The mentioned production method is highly productive and stable. The use of hyaluronic acid derivatives results in nanofibrous materials with a great sorption ability suitable for the treatment of chronic wounds. Such a medical device assures moist wound healing with all its benefits and it may also release antimicrobial substances eliminating the wound contamination. The 4Spin® technology allows to spin a high molecular weight hyaluronic acid by electro--blowing principle into randomly oriented nanofibers and into unidirectionally oriented nanofibers. The low molecular weight hyaluronic acid is not spinnable itself so it has to be blended with some spinnable fiber-forming polymer, polyethylene oxide was used in this case and the content of PEO may be decreased down to 1 wt. %. The stable production of vo-luminous and fluffy samples of hyaluronic acid was reached also by the 4Spin® technology (Ruzickova, 2013). Such 3D samples should be suitable for tissue engineering, drug delivery and wound dressings.
