PAMAM dendrimers are widely used in a variety of automated immunoassay and molecular diagnostic clinical platforms. The dendrimer improves analysis speed and sensitivity and a wide variety of antibody and signaling moieties can be conjugated to its surface. Detection of several cardiac markers and allergens are commercially performed and applications continue to expand. They can also be used in lateral flow immunoassay schemes (tabs) with enhanced detection sensitivity. Commercial use is also seen in molecular diagnostic/PCR amplification schemes targeted at rapid infectious disease identification including nosocomial infections. Additionally, PAMAM dendrimers are utilized in non-antibody based universal phosphoprotein detection, using specifically modified surfaces.
