2 October 2026. Ceres Nanosciences, Inc. reported results from a study evaluating Nanotrap® Microbiome A and B Particles combined with the Nanotrap® PRIME Extraction Kit for concentrating, extracting, and detecting mosquito-borne arboviruses from wastewater. The poster was presented by Saunders, Ceres Nanosciences, at the IWA World Water Congress & Exhibition (2026).
Wastewater samples were spiked with West Nile virus, dengue virus, Zika virus, chikungunya virus, and yellow fever virus. Nanotrap Microbiome A and B Particles captured all five viruses. West Nile, dengue, and Zika were simultaneously recovered from four unique wastewater samples spiked at 10⁴ copies/mL.
Chikungunya and yellow fever were detected across concentrations ranging from 10 to 1,000 copies/mL by both qPCR and dPCR. Reported endogenous chikungunya concentrations in wastewater are approximately 100–1,300 copies/mL. Yellow fever was detectable at 10 copies/mL.
Microbial capture and concentration used Nanotrap Microbiome A and B Particles, followed by nucleic acid purification using the Nanotrap PRIME Extraction Kit. The workflow processed 10 mL wastewater samples, while the authors note that 10–35 mL inputs are appropriate for native arbovirus isolation. Nanotrap-enriched nucleic acids were analyzed using Bio-Rad CFX96 qPCR and QIAGEN QIAcuity® One dPCR platforms.
The study demonstrates that Nanotrap Microbiome Particles combined with the Nanotrap PRIME Extraction Kit can capture and enable detection of five medically important arboviruses from wastewater, including chikungunya and yellow fever at concentrations as low as 10 copies/mL under the tested conditions. The workflow is faster than previously described arbovirus wastewater concentration methods and can be performed in automated or semi-automated formats. As a proof-of-concept based primarily on contrived wastewater samples, further validation with endogenous arbovirus-positive wastewater will be important.
Source: Ceres Nanosciences, Inc. news
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