Contains all standard system tubing including waste and input. Tubing kit designed for use with Top Connected Sunnies. For use with legacy edge connected Sunnies, the Sunscreen Alternative Tubing Configuration Pack (7206084) will be required Compatibility: This consumable is compatible with Sunscreen. SKU: 7206171
The primo nanoparticle synthesis platform for high-throughput formulation screening Crank out automated nanoparticle formulation screening Sunscreen automates nanoparticle formulation screening using microfluidics to rapidly generate low-volume nanoparticle samples. With automated reagent handling, sample collection and in-place cleaning, it produces highly consistent, ready-to-test particles in minutes-so you can screen more payloads and formulations than ever before. - Microfluidic precision: Generate uniform nanoparticles with supreme consistency in controlled microfluidic flow paths – less than 1% CV over 90 runs. - Low reagent consumption: Run 400 µL (3:1 ratio) experiments with as little as 100 µL per reagent input, minimizing material waste while maximizing data. - Range of reusable mixers: Sunnies (microfluidic mixers) come in a range of geometries and are manufactured from glass and automatically cleaned in place after every experiment, keeping running costs and hands-on time minimal - No cross contamination: Automatic cleaning of all wetted parts of the system between every experiment ensures no reagent carry-over and guarantees high-integrity samples. - Scale-ready results: Sunscreen uses the same pumps and mixers as Sunshine and Sunbather, ensuring seamless process transfer from screening to GMP. Find your flow With your plates loaded, you’re ready to mix up your nanoparticles with a Sunny. Sunnies are infinitely reusable and come in a range of geometries and sizes, with 9 different options to suit any application. Sunnies can be swapped in seconds, are cleaned after each experiment and when you’re ready to turn up the volume they can run longer than you can. Set it, forget it Tell Sunscreen’s Sunny Suite Software what’s in your plates, the mixing ratios, flow rates, and you’re ready to go. Built-in validation checks each experiment so that your run goes off without a hitch. With an entire plate of nanoparticles knocked out way before the day is done, you’ll still have plenty of time to start buffer exchange or characterization ahead of clocking out. Do more with less Nucleic acids typically cost a ton and are difficult to make. Sunscreen lets you flex concentrations and volumes to use way less of these precious payloads, saving lots of dough while you hunt for the MVPs. Add in reusable consumables and less than 15 minutes of instrument hands-on time to make 96 formulations, and you’ll walk away with your winners in no time. Bank on it When Sunscreen churns out a plate, you can trust that each formulation will be made consistently. Automated washing between experiments ensures no carryover from the last formulation, so a not-so-good formulation won’t affect the next good one. If you really want to supercharge your workflow, grab Stunner AF (Add Fluorescence) to check on your particle size, payload quant, and encapsulation efficiency to suss out your winners. Narrow it down Sunscreen helps you test a ton of formulations so you can sort the good from the bad, finding the right formulation combo to nail the payload and particle delivery performance you need. When you’re ready to optimize the killer top-tier formulations you find on Sunscreen, they can be transferred directly to Sunshine and on to Sunbather – the Sunny too.
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The all-purpose automated nanoparticle synthesis platform for process development & production The whole nanoparticle synthesis shebang Sunshine brings precision microfluidics to nanoparticle process development and production. With 3 different configurations, Sunshine can be used for anything from fast payload encapsulation, low-volume screening of mixing conditions, continuous nanoparticle production, to fully automated multi-experiment runs–all on a platform that scales effortlessly from milliliters to liters. - From milliliters to liters: Generate quality particles from 1 mL to multiple liters with Sunshine-perfect for both process optimization and pre-clinical production. - Range of reusable mixers: Sunnies (microfluidic mixers) come in a range of geometries and are manufactured from glass and automatically cleaned in place after every experiment, keeping running costs and hands-on time minimal. - No cross contamination: Automatic cleaning of all wetted parts of the system between every experiment ensures no reagent carry-over and guarantees high-integrity samples. - Fast, simple nanoparticles: For a quick and easy encapsulation of a single payload, Sunshine Single gets straight to the point, producing as little as 400 µL of particles in less than 5 minutes. - Multi-experiment automation: Sunshine and Sunshine Lite can automatically execute a series of experiments from the same injected reagents, allowing rapid screening of process conditions to find perfect particle performance fast. - Seamless transfer to GMP: Processes developed on Sunshine transfer directly to Sunbather for GMP manufacturing with identical pumps and mixers. Find your flow Fill one syringe with payloads, the other with lipids or other nanoparticle building blocks, and you’re ready to mix up your nanoparticles with a Sunny. Sunnies are infinitely reusable and come in a range of geometries and sizes, with 9 different options to suit any application. Sunnies can be swapped in seconds, are cleaned after each experiment and when you’re ready to turn up the volume they can run longer than you can. Sunshine wherever you’re at Wherever you’re at in development, there’s a Sunshine to suit. Fully featured Sunshine covers all the bases to take your nanomedicine from development to manufacturing. For exploring novel nanoparticles without in-line dilution, grab a Sunshine Lite. If you’re looking for a one-by-one, walk-up-and-run nanoparticle maker, Sunshine Single is ready to mingle. When you’re ready for the next step, you can trade-up to whichever Sunshine fits the bill. Dial it in Size really does matter for nanoparticle performance – Sunshine fully automates flow rate ratio, total flow rate and dilution experiments to help you size your particles right and keep them stable, with spot-on repeatability. Set your parameters for each individual experiment, and let Sunshine serve them up. Game for anything Sunshine can be used to produce a wide range of different nanoparticle types, including LNPs, polymer nanoparticles, liposomes, and other novel particles. The chemically resistant flow path means you can work with all sorts of solvents and reagent types without worry, so you can finesse your chosen particles in record time.
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The first plate-based DSF & light scattering platform to rule protein stability Dominate protein stability with plate-based DSF and light scattering Aunty combines full-spectrum DSF and light scattering (SLS and DLS) into the highest throughput protein stability characterization tool on the planet. See exactly when your proteins unfold and aggregate as temperature rises, compare stability across concentrations, or track long-term structural integrity under constant conditions. With its 96-well quartz plate, 8 µL samples, and blazing read speeds, Aunty shows exactly how your proteins will hold up. - Tm & Tonset: Full-spectrum DSF pinpoints melting behavior to compare stability across candidates and formulations - Tagg & Tsize: SLS and DLS show you when aggregation starts and how size shifts as your protein is heated up – key for formulation robustness - kD, B22 & G22: Light scattering reveals molecular interactions that predict stability and formulation behavior - Isothermal stability: Track how your protein holds up under constant conditions over time, to confirm real-world stability - Viral vector stability: Aunty keeps an eye on your vector capsid and its payload – because stable yet empty vector does not help Check out high-throughput protein characterization with Aunty Hi. I'm Andre, and I'm here to introduce you to Aunty. Hey. The fastest and highest throughput protein stability characterization tool on the planet. Planet. Planet. Planet. Aunty is the queen of high throughput protein stability characterization. Get out of the picture. Cut. Now let's get back to the real queen, shall we? Can I borrow that? Thank you. By combining full spectrum fluorescence, static light scattering, and dynamic light scattering, Aunty rules accurate thermal, colloidal, and long term stability experiments on up to ninety six samples in no time, making it the greatest of all time solution for high throughput stability characterization of your proteins. When screening stability of your proteins, it's easy to get behind with how many samples you have to run and all the parameters you need to measure. Not to mention, when it comes to analysis at the end of it, you've got data scattered all over the place. Let's see how Aunty helps you stay on top of all your stability screening. It all starts with the Aunty Plate. The Aunty Plate is the first ever ninety six well SBS format quartz glass stability consumable designed solely to help you get stellar optical performance and provide universal compatibility. Each well just needs eight microliters and is sealed tight. So your samples are locked in and contaminants stay out. Now we'll just get our thermal stability experiment set up in Aunty software. First, we name our experiment. And then we define our plate layout, either by just selecting wells or by importing a sample list from an Excel file. Finally, we review the ramp parameters and the measurement parameters. As the last step, Aunty shows an experiment summary to review and double check our experiment, and we're ready to go. Now, we just load our plate, and Aunty is going to rally up this thermal stability measurement in no time. Yum. Let's check out our results. Aunty determines unfolding of your protein by following the fluorescence emission during the thermal run. And it keeps track of aggregation at the same time to light scattering. Of course, we can also see how big the aggregates are as they form and how big they get. In addition to thermal stability experiments, we can also use Aunty to look into colloidal stability and long term stability of your samples. And no worries if you're looking to compare data from different experiments. Aunty software lets you compare up to three hundred and eighty four samples at a time. Now that you've seen how Aunty helps you characterize,
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The ultimate tool for single-particle biophysical characterization of lentivirus & exosomes from crude or purified samples Leprechaun uses antibody capture, interferometric sizing, and 3-channel fluorescence imaging to rapidly capture, count, size and characterize lentiviral and extracellular vesicle particles from crude or purified samples. It delivers single-particle sizing plus surface protein or cargo detection for complete particle analysis on up to 16 samples per run. - Lenti quality from crude samples: Measure the size and purity of lentivirus directly from in-process samples to catch poor-quality batches early in development. - Exosome results from biofluids: Detect and characterize exosomes straight from serum, CSF or other biofluid— no isolation step needed — so rare populations aren’t lost. - Custom capture: Use your own antibodies to capture specific viral vectors or EV subtypes for tailored biomarker or cargo analysis. - Sub-population analysis: Co-localize fluorescence markers to see which particles carry payload, have intact capsid, or express specific surface proteins. - Particle sizing: Determine particle size and size distribution to verify batch consistency and cargo integrity. - Contaminant detection: Quantify free p24 capsid or co-purifying EVs to fine-tune purification and improve QC. Leprechaun characterizes vectors like lentivirus and exosomes — on up to 16 samples at a time. The Luni consumable is where 1-25 μL of your vector is captured, sized, and then the structure of every particle is identified using immunofluorescence. Out-of-the-box kits with step-by-step protocols deliver answers in just a few hours. Rack up complete biophysical characterization of each lentivirus particle at every stage of the production process. Capture lenti down to 1x10 7 particles/mL using our antibodies or yours, then size them up to sort out individual viruses from aggregates. Confirm how many of your viruses have a capsid with fluorescent antibodies while RNA dye lights up the ones that have that critical nucleic acid on board. Leprechaun can tackle any lentivirus, whatever the flavor. Counting up how many of your lentivirus contain RNA at the first step of your process is tricky with all the cellular junk in upstream samples. Leprechaun’s RNA Kit pulls back the curtain at harvest to reveal which batches have the highest quality starting material. Move ahead with only the best preps and leave the trash behind. Dig into the details to see if your clean-up steps are doing their job with the Lentivirus EV Contaminant Kit. Ensure your batch isn’t full of undercover EVs pretending to be virus. Figure out how much p24 is inside viral particles and how much is roaming free as a soluble contaminant. For the first time you can monitor titer, structure and purity throughout your whole process. Getting a total concentration for your exosomes is tricky and confirming that your cell line made what you want is crazy hard. Leprechaun gets exosome concentration in a jiff by grabbing them by a slew of surface proteins, sizing them up and doubling-down with
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