The team has vast expertise in cloning, expression, protein purification, protein crystallization, X-ray diffraction data collection, structure solution and refinement. In the past three years, this department has delivered structures for more than 25 unique target proteins, over 100 ligand-bound structures, evaluated and refined more than 4000 structures of 100 different target proteins and carried out manual annotation for about 40 million protein crystal images. Scientists in the team have extensive prior experience in solving novel structures using different phasing methods, as demonstrated by over 20 peer-reviewed publications. The department also supports a client’s integrated drug discovery program run at our center to facilitate rational drug design. The team has beam-line access at the Synchrotron in the USA and Europe to obtain a high-resolution structure with faster turn-around time. The Structural Biology team provides the following functional services: - Gene-to-Structure. - Protein Expression, Purification, Characterization and Assays. - Protein-to-Structure. - Cloning and Expression. - Ligand-bound Structure Determination and Refinement.
Compiled from https://www.jubilantbiosys.com
