Neuropathic Pain Models: CCI/SNI/PSNL models (rats & mice); SNL model (rats); Formalin induced nociception; Capsaicin induced nociception. Disease Specific Pain Models: Chemotherapy induced mechanical allodynia; Bone cancer pain model; Streptozotocin induced diabetic neuropathy. Inflammatory Pain Models: CFA induced mechanical hyperalgesia; Dexamethasone induced muscle atrophy in mice; Isolation of various brain regions using brain matrices; Experience in target validation and development of target engagement models. Alzheimer’s Disease / neurodegeneration Models: MOG-EAE model of multiple sclerosis in rats and mice; Intrathecal / stereotaxic surgeries to inject compounds in different parts of spinal cord and brain; Collection of CSF in rats; PK-PD Correlations using free tissue and brain concentrations.
Compiled from https://www.jubilantbiosys.com
