SARomics Biostructures’ integrated structural biology services include fragment screening and hit identification using crystallography and NMR spectroscopy, as well as WAC™ screening techniques. WAC™ is a proprietary method jointly owned by SARomics Biostructures and our partner, RG Discovery. The method uses a chromatography column to inject a solution of fragments or lead-like compounds. During elution, the fragments with a higher affinity for the protein will stay on the column longer than those with a low affinity. Mass spectrometry can conveniently detect and identify the fragments, thus establishing a direct ranking of hits. WAC™ is an efficient, high-throughput, and lower-cost alternative to other biophysical screening methods.
