By National Nanotechnology Center (NANOTEC)
Enhancing the Capability of Zebrafish Testing Laboratories through OECD GLP Compliance to Strengthen the Competitiveness of Thailand's Cosmetics, Medical and Healthcare, Agriculture, and Food Sectors. Thailand has been officially recognized as an adherent to the Mutual Acceptance of Data (MAD) system under the OECD Principles of Good Laboratory Practice (GLP) for non-clinical safety testing of chemicals in seven product categories. This recognition aims to reduce animal testing, minimize redundant testing, and support exports to over 45 OECD member countries. Test reports from OECD GLP-certified laboratories can be submitted for regulatory approval in these countries, streamlining registration processes and reducing costs for international market access. Currently, Thailand has only seven OECD GLP-certified laboratories, none of which utilize small vertebrate models such as zebrafish. Zebrafish are internationally recognized as a valuable model organism due to their genetic similarity to humans (up to 70%), presence of key organs found in humans, and suitability for pharmacological and toxicological testing. Their advantages include requiring smaller sample volumes, shorter testing times, lower costs, and the ability to test large numbers of organisms per experiment. Therefore, establishing an OECD GLP-certified zebrafish testing laboratory in Thailand would strengthen the country's national quality infrastructure, reduce reliance on larger vertebrate animals, shorten testing timelines, and lower associated costs. Ultimately, this would contribute to the development of safety data for food and drug-related substances, support Thailand's industries in achieving international safety standards, and decrease long-term dependence on overseas testing services.
