Electrochemistry in Organic Synthesis In recent years electro organic synthesis has emerged as a promising green methodology in organic chemistry and a quick alternative to conventional organic synthesis in academic labs. Several breakthrough research papers using electrochemical reactions which are alternatives to Birch reduction by avoiding the use of Na/Li-metal, reduction of amide to an amine by avoiding the use of pyrophoric LAH or borane in a scalable manner, reduction of the double bond to single bond by avoiding Pd/C, epoxidation without the use of peroxide reagent, and chemoselective reduction of hetero arenes, have attracted chemical industries to adopt this new technology. Other high potential reactions such as decarboxylative sp3-sp2 and sp3-sp3 cross-coupling, O-arylation of alcohols, sulfonylation of aryl halides, and dimerization of amine are successfully carried out using electrochemical reactions. All these reported new methods have drastically reduced the number of steps compared to conventional synthesis, reducing time and waste by improving yield. Jubilant Biosys is committed to this cause and has a dedicated team of scientists exploring novel methods to cater to the needs of our clients, and the recent launch of ElectraSyn 2.0 by IKA has helped us in this endeavour. Our Capabilities PhotoRedox Chemistry After the first report of the PhotoRedox reaction by Prof. David MacMillan in Science 2008, there has been exponential growth in this field. A search in Reaxys with the code word “PhotoRedox Reaction” showed nearly 900 publications in 2021. In the last ten years, PhotoRedox catalysis has moved from academic research labs to industrial curiosity. According to Prof. MacMillan, every pharmaceutical company he visited is now doing PhotoRedox in medicinal chemistry, and thousands of drug-like compounds are being generated this way. Many catalytic conversions like C-C bond forming (sp3-sp2 and sp3-sp3 cross-coupling), cycloaddition, challenging functional group conversion, and unusual rearrangement, which were either not feasible through conventional methods or lengthy routes are achieved using PhotoRedox reaction. Jubilant Biosys is actively working on this technology by using a Penn PhD Photoreactor with a dedicated team of 10 scientists who are well-trained and efficient in successfully screening reaction conditions carried out several C-C bond formation reactions as well as functional group transformations. Jubilant has been supporting many of its collaborators through this new technology to test challenging and novel reaction conversion. We are now focusing on continuous-flow photochemistry by combining our flow reactor with a photo reactor, which will have excellent potential for scalability Our Capabilities Comprise of
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