By BioNavis Ltd
MP-SPR instruments measure affinity and kinetics of the molecular binding reaction without the burdens of labelling. The MP-SPR flow injection principle rapidly brings the sample into the measurement area (the so-called flow cell). Continuous measurements reveal how quickly molecules in the flow (analyte) bind to the surface-attached ligand molecule and how strong the interaction is. After the sample injection, buffer is again flowed into the measurement area. This measurement principle allows data to be fitted with binding models, revealing binding steady-state affinity and association and dissociation rate constants. The data analysis software contains multiple fitting models suitable for different interacting partners (e.g., small molecules, antibodies, etc.).
