Iron nanorobots go undercover
Living cells inside the body could be placed under surveillance--their location and migration noninvasively tracked in real time over many days--using a new method developed by researchers at KAUST.
The technique uses magnetic core-shell iron nanowires as nontoxic contrast agents, which can be implanted into live cells, lighting up those cells' location inside a living organism when scanned by magnetic resonance imaging (MRI). The technique could have applications ranging from studying and treating cancer to tracking live-cell medical treatments, such as stem cell therapies.
Jürgen Kosel and his team recently showed that core-shell iron nanowires could selectively kill cancer cells with a combination attack, delivering an anticancer drug into target cells while also puncturing the cell's membrane and unleashing blasts of heat. Now, in collaboration with researchers from the CIC biomaGUNE in San Sebastian, Spain, the team has shown that the same type of iron core, iron-oxide shell nanowires, can be used for noninvasive medical imaging. The nanowires could potentially be used as "theranostic" agents, able to identify, track and then take out target cells.
"Cell labeling and tracking has become an invaluable tool for scientific and clinical applications," says Aldo Martínez-Banderas, a Ph.D. student in Kosel's team. "One of the key aspects of cell tracking studies is the sensitivity to detect a small number of cells after implantation, so the strong magnetization and biocompatibility of our nanowires are advantageous characteristics for MRI tracking."
The nanowires performed well as MRI contrast agents, even at very low concentrations, and the magnetic response could be tuned by altering the thickness of the nanowire shell, the team showed. The nanowire's biocompatibility permitted long-term tracking of the live cells. "The nanowires interacted with cells without compromising their survival, functionality or capacity to proliferate," Martínez-Banderas explains. The labeled cells could be tracked either in cell cultures or once injected into a living animal. "The strong magnetization of the nanowires enabled the detection of approximately 10 labeled cells within the brain of a mouse for a period of at least 40 days, which allowed us to trace their exact location and fate in the animal," Martínez-Banderas says.
"These core-shell nanowires have various additional features, including the ability to control them magnetically to guide them to a particular location, to carry drugs, or be to heated with a laser," Kosel says. "Combining all of that with the capability of tracking creates a theranostic platform that can open the door for very promising new approaches in nanomedicine."
Magnetic core–shell nanowires as MRI contrast agents for cell tracking
Aldo Isaac Martínez-Banderas, Antonio Aires, Sandra Plaza-García, Lorena Colás, Julián A. Moreno, Timothy Ravasi, Jasmeen S. Merzaban, Pedro Ramos-Cabrer, Aitziber L. Cortajarena & Jürgen Kosel
Journal of Nanobiotechnology volume 18, Article number: 42 (2020)
KAUST Associate Professor (Adjunct), Electrical Engineering
King Abdullah University of Science and Technology (KAUST)