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Strategic partnership to accelerate the next generation of personalized medicine

June 22, 2022 08:00 AM Eastern Daylight Time

Ligandal Partners With Nanotronics to Solidify Optimization and Quality in Personalized Genomic Medicine Delivery Systems

Ligandal Inc., a leader in personalized genomic medicine, biomaterials, and AI and Nanotronics, a developer of advanced intelligent inspection systems and production hardware for adaptive manufacturing, today announced a partnership to commercialize, develop, and provide next-generation technologies for gene therapy, peptide materials, nanomaterials, and characterization of biological technologies.

“This platform and partnership also help bridge gaps between the long-standing health inequities and disparities faced with current-generation medicine.”

Together, the two companies will implement future modular fabrication laboratories and inspection hardware as part of nanomedicine and nanomaterials-related development. Ligandal’s new headquarters will also be in The Brooklyn Navy Yard to ensure a cohesive ecosystem, effective collaboration, and generation of new product candidates and laboratory infrastructure.

“The Nanotronics-Ligandal partnership further solidifies New York as a life sciences and advanced manufacturing hub, boosting the ecosystem of great companies we have across the city, specifically in Brooklyn,” said Lindsay Greene, President & CEO of the Brooklyn Navy Yard. “This union of companies will not only continue to create new products at the forefront of life enhancing treatments but will also enable Nanotronics to continue to build and invest in local NYC talent pools that support their growth and innovations,” she continued. “This combination of accomplishments embodies many equitable and inclusive economic development principles and is thus a huge win for New York City and the Brooklyn Navy Yard.”

The companies will work together to create next-generation nanomaterials and end-to-end capabilities to design, characterize, synthesize, and support multiple therapeutic initiatives, including in rare disease-related applications, hematology, infectious disease, and biodefense. Ligandal has demonstrated efficient delivery to bone marrow, immune cells, and rare blood cell populations, as well as >99% inhibition of the virus that causes COVID-19 using its innovative peptide and nanoparticle-based delivery technologies.

“The purpose of this partnership is to scale rapidly, producing the next generation of cell and tissue-specific delivery technologies and synthetic peptides with the highest yields possible, while accelerating the translational development of much-needed precision therapeutics,” said Andre Watson, CEO and Chair of Ligandal. “This will allow the delivery of gene therapies exactly where they need to go, with precision and without the issues seen with viral delivery systems,” he continued. “We think this strategic partnership brings promise to the next frontier of medicine, biotherapeutics, and manufacturing.”

To fast-track Ligandal’s therapeutic programs and demonstrate the safety and efficacy for clinical applications, the company is pursuing a development path around rare hematological genetic diseases, immuno-oncology, and biodefense applications including conducting further trials with live SARS-CoV-2 virus with the National Institute of Allergy and Infectious Diseases (NIAID) and National Institutes of Health (NIH).

“The opportunity and synergies gained here will range from preventing and treating genetic diseases and correcting broad metabolic and degenerative disorders to augmenting and promoting a more robust immune response to the likes of COVID, other emerging infectious diseases, and cancers,” said Dr. Daniel B. Fagbuyi, Chief Medical Officer & EVP for Ligandal and former Obama Administration Biodefense and Public Health appointee. “This platform and partnership also help bridge gaps between the long-standing health inequities and disparities faced with current-generation medicine.”

Ligandal has demonstrated rapid, predictive capabilities to generate peptides to mimic biological interactions, driven by an AI-based approach for simulating, designing, and synthesizing cell-specific targeting technologies for gene therapy, editing, and beyond.

“We are incredibly honored to work with Andre and his team to advance personalized genomic medicine and will deploy our engineers as quickly as possible to optimize the manufacturing of their delivery technologies every step of the way using our proprietary AIPC™ Platform,” said Dr. Matthew Putman, CEO, and cofounder of Nanotronics.

About Ligandal

Ligandal is developing next-generation, precision genetic nanomedicine and delivery technologies for gene editing, gene therapy, regenerative medicine, and pandemic defense biotechnology applications. The company uses computational biology, machine learning, and AI with a novel platform for cell-specific and tissue-specific delivery and next-generation nanomaterials. Ligandal develops peptide-based technologies for gene therapy, gene editing, regenerative medicine, immunotherapy, and advanced antidote-vaccine technologies, and utilizes computational biology approaches to predictively generate approaches for delivery to and modulation of various disease states.

​Ligandal’s lead efforts are in hematological gene editing, in addition to a pandemic mitigation platform, tailored for COVID-19 as SARS-BLOCK™, which was designed as an early treatment and prophylactic against the virus that causes COVID-19. Ligandal has numerous discovery-stage programs for the treatment of rare diseases and cancers using their peptide-based, novel nanomaterials platform.

About Nanotronics

Nanotronics is an advanced machines and intelligence company that helps customers across the public, private, and nonprofit sectors solve the unique inspection and process control challenges of precision manufacturing. A leading developer of automated optical inspection tools for the semiconductor industry, Nanotronics uses hardware and software to provide industrial-scale, high-throughput, super imaging systems.

Deployed across fifteen countries and industry agnostic, Nanotronics works with leading-edge companies, from aerospace to electronics and healthcare, to drive up yield, reduce footprint and waste, lower costs, and speed up design iteration, while eliminating laborious manual inspections.

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Mary Cunney

Chief Marketing and Communications Officer, Nanotronics

Jack Kerwin

Director of Strategy and Business Development, Nanotronics

NWA Magazine - Nov2023 - Cover - Final.PNG

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