InoMATRIX Morphlology kit allows you to select optimal morphology of fibers for your cells.
The μSphere technology is based on electrohydrodynamic atomization, where the polymeric liquid is atomized by strong electric field. Such method enables production of small and uniform droplets resulting in uniform production of particles with size from 100nm to 10μm. μSphere particles may serve as drug delivery vehicles.The unique feature of our μSphere products is a tunable release facilitating complex release profiles. The core/shell structure of particles protects the embedded proteins, DNA and drugs susceptible to environmental damage. Programmable release and mild immobilization of active molecules enable production of next generation drug delivery systems applicable in pharmaceutical, nutrient and tissue engineering applications. Nano and microparticles produced by µSphere technology enable encapsulation of diverse bioactive molecules. The technology enables encapsulation to both monolithical (single phase) and multi-material (multi-phase) systems. The technology is especially useful for applications where the produced material have to be easily dispersed into various oils, creams, and powders or applied to systemic administration. The µSpheres are prepared on request with custom range of active molecules. The nano/microparticles are delivered in dry or dispersed form according to users requirements. Industry/field - What can be delivered: Diet supplements: Vitamins & minerals, Fitness and body building supplements, Probiotic cultures, Regulated delivery of plant extracts Cosmetic use: Small molecules, Hyaluronic acid Pharmaceutical use: Anticancer drugs, Cardio-logical drugs, Antibiotics, Ocular drug delivery Tissue engineering: Composite foams, Composite hydrogels, Nano/microparticles scaffolds Technical use: Combination with nanoparticles and inorganic materials, Encapsulation of fluorescent dyes and nanoparticles for flow cytometry and cell biology imaging, Formation of coatings (e.g. UV protection, nanostructured coatings)
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InoMATRIX provides optimized 3D environment for your cells. During classical 2D cultures the cells are growing in monolayers and their morphology, expression of genes and behaviour is altered. This may alter reliability of 2D cell culture results. The key advantages of InoMATRIX are: - Fibrous morphology mimicking ECM – InoMATRIX Morphlology kit allows you to select optimal morphology of fibers for your cells. - High specific surface enables efficient cell adhesion. - Porous structure allows diffusion of nutrients – InoMATRIX has porosity 80% which keeps your cells in contact with environment. - Flexble structure with inteconnected pores – InoMATRIX has total pore interconnection enabling cells to penetrate into the fibrous mesh. - Easy manipulation – scaffolds have sufficient mechanical properties for manipulation during experiments. - Large number of formats – InoMATRIX comes in form of standard microplates, inserts or custum shapes. - Compatibility with standard methods. Polycaprolactone has negative zeta potential and enables adhesion of ECM proteins including collagen, laminin and fibronectin. The standard thickness of InoMATRIX membrane is 200 µm. However, we offer custom fabrication of scaffolds with other thickness. In case of nanofibrous scaffolds (NF) the pore size is about 1.5 µm. In case of microfibrous scaffolds (MF) it is about 6 µm. In case of nano/microfibrous scaffolds it is about 3 µm. In case of porous scaffolds (PF) the interfibrillar pores have size about 3 µm.However, the fibers are flexible and have high porosity (80%) and enable cell penetration across the scaffold. InoMATRIX products (especially Inserts) are very compatible with hydrogels. The hydrogel can be formed on surface of fibers and support the cells. Our Insert membranes are having biomimicking structure and high porosity (80% for InoMATRIX compared to 10% in case of track-etched membranes). You can use them as replacement of standard inserts with non-biomimetic surface.
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The unique feature of InoCure advanced nanofibrous products is a tunable release facilitating complex release profiles. The structure of fibers protects the embedded proteins, DNA, nanoparticles and drugs susceptible to environmental damage. Programmable release and mild immobilization enable production of next generation systems with complex release profiles. InoMATRIX enables custom encapsulation of diverse macromolecules including: The advanced fibers are prepared on request with custom range of active molecules. The fibers are available in form of bulk sheets (up to 40cm wide), 12-,24-, 48-, 96-well inserts or custom sheets and well inserts (CellCrown or hanging well inserts). Application - What can be delivered: Cell proliferation: Growth factors (e.g. bFGF, PDGF, EGF), Platelet rich plasma Cell differentiation: Growth factors, Differentiation media components Tissue engineering: Scaffolds for cell and cell-free tissue engineering Molecular biology: Organotypic models, Feeder replacement, siRNA release Cosmetics: Protection of active substances (e.g. hyaluronic acid, natural extracts, essential oils), Stabilization of proteins and peptides, Bioactive non-woven textiles (e.g. masks, skin patches, wound dressings) Food and nutraceuticals: Vitamins and minerals, Fragrances, Protection against oxidation
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Precise regulation of temperature and humidity. As it is known, electrospinning is very versatile and economically efficient process. But the optimization is very challenging because of the fact, there are lot of parameters needed to set up. To improve reproducibility of the electrospinning process, InoCURE designed and brought to the market Air Conditioning Unit called „InoCOOL“. Many publications showed how important tightly controlled environment conditions are, in order to stabilize the process and to obtain reproducible morphologies. In addition, the unit is fully integrated which means there is no additional lab space needed. To control temperature and humidy can be really game-changing for your research or scale-up process. - Robust construction and high-quality materials used - Wifi connection - Full software integration - Compatibility with any commercial electrospining device If you are intersted in more indormation about the compact air condition system compatible with your electrospinning/electrospraying device, please, dont hesitate to contact us.
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