Electro-chemical liquid-cell TEM holder enabling atomic resolution Electro-chemistry at the atomic scale Volta is the first ever commercial solution for atomic resolution imaging inside an electro-chemical flow cell. Developed by Insight Chips in partnership with DTU. Book a call with us to discuss how the solution may help you. First atomic resolution data Atomic resolution of electrodeposited zinc grown from a 0.1 M ZnSO4 solution, captured on a Titan equipped with a Gatan OneView detector. It’s only going to get better! This image was with our very first prototype chip with a whopping liquid thickness of 270 nm! We just got new chips out from the clean room with liquid thickness down to 40 nm. The corresponding CV for the ZnSO4 experiment, with a scan rate of 100 mV/s. This curve is also produced with our first prototype which only had 2 electrodes. Our new version has 3 electrodes. Book a demo with one of our prototypes
The world's first of its kind – for use in TEM, SEM, synchrotrons and optical microscopes The Nano Channel Chip is based on 10 years of prof. Kristian Mølhave's research and development at the Technical University of Denmark. It aims to introduce a higher level of reproducibility, resolution, flow control and ease-of-use than any other liquid-cell. The Nano Channel Chip fits in our holders for TEM (JEOL and TFS), SEM and optical microscopes. No assembly needed: The chip is made in one piece so there is simply nothing to assemble. There is no cleaning necessary either, as the inlets seal the chip and the internal channel system remains chemically clean until the membranes are broken by a flow through the chip. Prep-time is less than 5 minutes! Well-defined liquid thickness down to 5 nm! Membrane bulging is also not an issue. Each channel is 1-2 µm wide and therefore typically bulges less than 10 nm inside the TEM. Silicon-nitride membranes down to 10 nm! This has enabled customers to consistently attain Å resolution in the TEM. Four individually controlled in/outlets in the chip: These four in/outlets create two bypass channels inside the chip. Two of them can be used as inlets, the other two as outlets. Being very large – 100 µm wide and 15 µm deep, liquids can be flushed into the chip in about a second and exchanged in just a few seconds. Unprecedented flow control and mixing directly in the field of view: Two liquids from each bypass channel can be brought together in the field of view inside nano channels. The Nano Channel Chip is the first ever commercially available liquid cell that can mix directly in the field of view. Another benefit of the nano channels is that you will know exactly where the flow goes, since the channels are guiding the liquid exactly where you can see. Robust and reliable: Because the chips are already assembled with a firm wafer-bond, the suspended membrane can withstand a lot. In fact, you can drop the chips and they will survive. Also, you will not have to worry about tightening the lid on top of the chip too much, the chip can withstand it. Finally, the vacuum is the most robust of any liquid holder. Because the chip is so robust, it can be pushed very hard against sealing O-rings by the lid, creating a strong and reliable seal. Ease of use: Assembly and Disassembly in minutes. The Nano Channel Chip is an innovative piece of technology that has been designed to streamline complex laboratory procedures. One of the key benefits of the Nano Channel Chip is its ease of use. The chip is incredibly simple to set up and can be used by anyone, regardless of their level of experience. Screw off lid; Place the new chip in the holder; Screw on the lid again; Vacuum test holder and begin TEM session. A true nano-fluidic flow cell for TEM and SEM: The Nano Channel Chip turns a common microfluidic flow-cell structure into a truly nanofluidic one and makes it adaptable with electron microscopes. The chip has four inlets and an internal flow structure with two micron-sized bypass channels with nano channels connecting them. When a higher pressure is applied to one bypass channel, the liquid flows through the nano channels into the other bypass channel, and vice versa. Only the nano channels are visible in the field of view, whereas the larger micro/bypass channels are hidden away inside the chip to protect the TEM from leakage of a larger volume of liquid. The volume of a nano channel is on the order of femtoliters and poses no risk of breaking the vacuum in the column on its own. Even when a nano channel fractures during a TEM experiment, the column vacuum remains intact. The four inlets are sealed with O-rings in the tip of the holder and held in place with a lid. Tubes connect inlet ports in the backside of the holder to each of the four inlets in the chip. From there, the holder can be controlled with syringes or a pressure-based pump system. For this, we recommend using Fluigent's EZ Flow which can be used to control each inlet separately and precisely.
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Compatible with our high-tilt TEM liquid cell holder. XtaLAB Synergy-ED is a new and fully integrated electron diffractometer, creating a seamless workflow from data collection to structure determination of three-dimensional molecular structures. The key feature of this product is that it provides researchers an integrated platform enabling easy access to electron crystallography. The XtaLAB Synergy-ED is a system any X-ray crystallographer will find intuitive to operate without having to become an expert in electron microscopy. Technique: 3D microcrystal electron diffraction (MicroED/3D ED) with continuous-rotation data collection Attributes: Dedicated electron diffractometer running CrysAlisPro-ED, a complete integrated software platform. Ultra-low-dose operation for sample screening and diffraction data collection. Optimized electron optics for versatile diffraction conditions without the need for regular alignment or calibration. Automation features for unattended data collection from hundreds of microcrystals Detector: High-speed, high-sensitivity hybrid pixel array detector, HyPix-ED. Variable detector distance via electron-optical projection system (10x range) Source: LaB₆ electron gun, electron energy up to 200 keV (λ = 0.0251 Å). Three-stage electron-optical condenser system Goniometer: Side-entry, single rotation axis with 160° total range Accessories: Cryo-transfer device, low-temperature, heating, gas-cell, and inert-transfer sample holders. Elemental analysis (EDS/EDX) Computer: External PC, MS Windows OS– Modular and plug-and-play extendable Design
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Atomic resolution in liquids +/-70 degrees alpha-tilt Tomography and 3DED in liquids Alpha is our solution for everything the Atomos can do plus the ability to tilt 70 degrees in the TEM: - Atomic resolution in liquids - Flow and mixing of 2 different liquids+/-70 degrees tilting - Heating up to 120 C Alpha: Optimized for Alpha-tilt The innovation behind Alpha lies in making the chip extra thin, and extra long... This enables the holder to clamp the chip further down, far away from the pole piece in the TEM. A single screw and lid clamps the holder at the base, extending the long and thin chip in between the pole piece. There has been a patent filed for the solution. A micro-fluiding flow system for TEM 4 flow ports Creates two bypass systems inside the chip, which allow for fast and easy exchange of liquids, as well as mixing of two liquids directly in the field of view. Precise thickness 15-20 nm SiN membranes Liquid thickness anywhere from 0-5,000 nm Bulging only ~10 nm The four inlets of the chip are directly accessible from the backside of the holder, and liquid-flow and mixing can be done while the holder is inside the TEM, fully under vacuum. Heat up to 120 C The Atomos can heat the entire tip of the holder up to 120 C. It works by attaching a PCB board with resistive heaters and placing a sensor on the tip. An in-house made software then allows the user to set the temperature anywhere between 25 C and 120 C. A patent has been filed for this solution. System package Packaged in a hardcase suitcase with all the tubes, connectors and tools you need to get started
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The first-ever commercial liquid-cell system enabling atomic resolution reliably Atomic resolution liquid-cell TEM simplified With just minutes of preparation time, atomic atomic resolution imaging in liquids becomes possible! Atomos features - Atomic resolution in liquids - Flow and mixing of 2 different liquids - Heating up to 120 C A micro-fluiding flow system for TEM 4 flow ports Creates two bypass systems inside the chip, which allow for fast and easy exchange of liquids, as well as mixing of two liquids directly in the field of view. Precise thickness 15-20 nm SiN membranes Liquid thickness anywhere from 0-5,000 nm Bulging only ~10 nm The four inlets of the chip are directly accessible from the backside of the holder, and liquid-flow and mixing can be done while the holder is inside the TEM, fully under vacuum. Heat up to 120 C The Atomos can heat the entire tip of the holder up to 120 C. It works by attaching a PCB board with resistive heaters and placing a sensor on the tip. An in-house made software then allows the user to set the temperature anywhere between 25 C and 120 C. A patent has been filed for this solution. System package Packaged in a hardcase suitcase with all the tubes, connectors and tools you need to get started
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