Consider Upgrading to High-Amplitude Ultrasound While high-pressure homogenizers provide excellent results with NanoStabilizers®, upgrading to an ultrasonic processor offers distinct advantages: - Simplified Processing: Skip the pre-homogenization step with a rotor-stator high-shear mixer; simple stirring is all that’s needed. - Reduced Maintenance Costs: Avoid costly repairs to critical components and sealing surfaces caused by dissolved gases and entrained air introduced during pre-homogenization. - Lower Energy Consumption: Ultrasonic systems use significantly less energy than HPH systems, reducing operational costs while delivering superior product quality. - Effortless Scalability: ISM’s high-amplitude ultrasonic processors ensure consistent results on lab, bench, and industrial scales, eliminating the need for re-optimization after scale-up.
We are excited to spotlight the Ultrasonic Extractor Pro-Lite™ — a semi-automated ultrasonic extraction system from Industrial Sonomechanics, purpose-built for users scaling from R&D to pilot-scale production. Whether you are extracting alkaloids from kratom, cannabinoids from cannabis, polyphenols from botanicals, or bioactives from mushrooms, the Pro-Lite™ delivers the consistent, high-yield results you need — with minimal operator involvement. - Rapid extraction from plants, mushrooms, and microbial biomass - Reproducible, high-quality results during pilot-scale production - Replace harsh solvents with milder, greener food-grade alternatives - Precise temperature control for heat-sensitive substances - Batch sizes of 5–10 liters — ideal for pilot-scale processing - Designed for extended pilot-scale operation Product Overview Specifically designed for challenging, high-value extraction projects, ISM equipment combines high-intensity ultrasound with directly scalable process flow — a combination that is unique in the industry. High-intensity ultrasound enables efficient, high-yield extraction of alkaloids, cannabinoids, terpenes, polyphenols, recombinant proteins, and many other bioactives. In many cases, harsh organic solvents can be replaced with greener alternatives, such as ethanol or water, while still achieving superior results. The Pro-Lite™ is the standout choice for users who have completed laboratory-scale optimization and are ready to move into pilot-scale production without committing to a fully industrial system. It is designed for batch processing of biomass/solvent slurries on the order of 5–10 liters, with most extraction steps automated. The operator loads the material, selects the processing parameters, starts the system, and collects the extract when the process is complete for filtration and downstream processing. The Pro-Lite™ is built on ISM’s patented Barbell Horn® Ultrasonic Technology (BHUT), which enables high-amplitude ultrasound over extended radiating surfaces at any operational scale. Unlike conventional high-amplitude horns, which are largely limited to laboratory-scale use, BHUT allows results achieved at lab scale to be transferred directly to pilot and industrial production. Pro-Lite™ Ultrasonic Extractor for Pilot-Scale Production Presented recently by ISM Junior R&D Scientist James Marco, the Ultrasonic Extractor Pro-Lite™ is a semi-automated system purpose-built for the critical transition from laboratory optimization to pilot-scale production — the stage where many manufacturers struggle. With the Pro-Lite™, most steps of the extraction process are automated. The operator loads the biomass/solvent slurry, selects the processing parameters via the system interface, starts the process, and returns to collect the extract for downstream filtration and refinement. This hands-off workflow minimizes operator involvement, reduces variability, and supports consistent results across runs. The Pro-Lite™ is compatible with a wide range of botanicals and biomass types — including powdered kratom leaves, cannabis plant material, mushrooms, and other plant sources — and is effective for extracting alkaloids, cannabinoids, terpenes, polyphenols, recombinant proteins, and other bioactives. Who Is the Pro-Lite™ For? The Pro-Lite™ is ideally suited for manufacturers and R&D teams that have validated their extraction process at laboratory scale and are ready to move into pilot-scale production — but are not yet ready to commit to a fully industrial system. It occupies the critical sweet spot between benchtop R&D and large-scale manufacturing, providing true pilot-scale capacity with a 5–10 L batch size and a level of automation that keeps operation simple and results reproducible. Specific applications include, but are not limited to: - Kratom & Kava: High-yield extraction of mitragynine-rich alkaloids from kratom leaf material and kavalactones from kava root using food-grade solvents. - Functional Mushrooms: Efficient extraction of polysaccharides, beta-glucans, and other bioactives from lion’s mane, reishi, chaga, and other functional mushroom species. - Cannabis & Hemp: Rapid, high-yield extraction of cannabinoids and terpenes from plant material, with the option to use milder solvents while maintaining or improving extraction efficiency. - Botanicals & Nutraceuticals: Extraction of polyphenols, flavonoids, curcuminoids, and other plant-derived bioactives for use in dietary supplements, functional foods, and beverages. - Recombinant Proteins & Microbial Biomass: Cell disruption and protein extraction from bacterial, yeast, and algal biomass for pharmaceutical and biotechnology applications. The Pro-Lite™’s semi-automated design also makes it practical for facilities without dedicated extraction specialists — the system handles the processing while your team focuses on what comes next: filtration, formulation, and finished product development.
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Industrial-Scale Processor The ISP-3600 ultrasonic liquid processor is designed for industrial-scale production.It is suitable for working with liquid volumes above 1 L, with no upper limit. The ISP-3600 ultrasonic liquid processor comes standard with: 3600 W ultrasonic generator, water-cooled transducer, half-wave booster half-wave Barbell Horn®, flow-through reactor chamber (flow cell), heat exchanger, heavy-duty support stand, spanner wrench set, and noise reduction ear muffs. Optional items include: storage/mixing tank with integrated mixer, sound enclosure, magnetic stirrer with hotplate, peristaltic pump, water chiller, jacketed beaker, NanoStabilizers®, and post-processing filters. The ISP-3600 processor can be used in batch and flow-through configurations (see schematics on the left). Details are available under the SPECIFICATIONS tab. The ISP-3600 processor utilizes patented Barbell Horn® Ultrasonic Technology (BHUT), which makes it possible to generate extremely high ultrasonic amplitudes at any scale of operation. With the ISP-3600, any process optimized with our smaller units, the LSP-600 or BSP-1200, can be directly scaled-up to an industrial production environment, while maintaining the same processing conditions and reproducible results. Further scale-up is possible by placing several ISP-3600 processors in parallel and/or in series (see schematics on the left). MAIN COMPONENTS Ultrasonic generator (3600 W) - Input voltage: 220 Vac – 240 Vac @ 50/60 Hz - Rated current: 20 A max. - Output characteristics: 3600 W (max.), 20 (+/- 1) kHz, 3600 W (max.) - Additional features: continuous resonance frequency lock, automatic power adjustment, fine amplitude adjustment and lock (20 – 100 %), real-time monitoring of output power and frequency, optional external control, optional pulsed operation. Water-cooled piezoelectric transducer (SWCT-3600) - Output characteristics: amplitude — 24 microns (max.), frequency — 20 (+/- 1) kHz, power — 3000 W (max.) Half-wave booster half-wave Barbell Horn® (HBHB, 45 mm tip diameter) - Output characteristics: amplitude — 112 microns (max.), frequency — 20 (+/- 1) kHz, power — 3000 W (max.) Flow-through reactor chamber (flow cell) - Features: 1″ tri-clamp inlet and outlet. OPTIONAL ACCESSORIES - Half-wave Barbell Horn® (HBH, 45 mm tip diameter, amplitude — 94 microns (max.)) - Support stand with clamp holders - Storage/mixing tank with integrated mixer - Peristaltic pump - Water chiller - Magnetic stirrer with hotplate - Stainless steel jacketed beaker - Noise reduction ear muffs - Sound enclosure - Heat exchanger - NanoStabilizers® - Post-processing filters ADDITIONAL INFORMATION Materials of wetted parts: - Reactor chamber — 316 stainless steel. Food compatible. - Horns (HBHB, HBH) — Ti6Al4V. Food compatible. - Gaskets —Buna-N or Teflon. Food compatible. - O-rings — Buna-N. Food compatible. Noise level: - 106 – 109 dBa at 2′ away. Noise reducing earmuffs or sound enclosure required. Capacity - 1 L – 10 L —with HBHB (batch mode) - 2 L – unlimited —with HBHB or HBH + reactor chamber (flow-through mode) Productivity Rates - Productivity rates are highly dependent on the nature of each process and range from about 5 L/h for challenging tasks (e.g., top-down nanocrystallization of active pharmaceutical compounds) to over 250 L/h for fast processes (e.g., degassing, deagglomeration). - 4 – 5 times faster processing than with the BSP-1200 - 20 – 25 times faster processing than with the LSP-600 What is the ISP-3600 ultrasonic processor used for? The ISP-3600 is ISM’s 3600W industrial-scale ultrasonic processor for continuous, production-scale liquid processing. Applications include nanoemulsion production, extraction and cell disruption, degassing and deaeration, dispersing and deagglomeration, nano-crystallization, and petroleum fuel upgrading — in batch or flow-through mode with no upper volume limit. How does the ISP-3600 compare to the LSP-600 and BSP-1200? The ISP-3600 can produce 4-5x than the BSP-1200 and 20-25x than the LSP-600. All three use ISM’s patented Barbell Horn® Ultrasonic Technology, enabling direct scale-up without loss of amplitude, process conditions, or reproducibility. Can multiple ISP-3600 units be combined for higher throughput? Yes. Multiple ISP-3600 units can be arranged in parallel to multiply throughput or in series for more intensive processing — scaling production to virtually any required volume. What is the processing capacity and flow rate of the ISP-3600? Rates range from approximately 5 L/h for demanding processes like pharmaceutical nanocrystallization up to over 250 L/h for degassing or deagglomeration. Batch mode: 1-10L; flow-through mode: 2L to unlimited. Is the ISP-3600 certified for food and pharmaceutical use? Yes. All wetted parts — 316 stainless steel reactor chamber, Ti6Al4V titanium horns, Buna-N or Teflon gaskets — are food compatible. The system carries CE and TÜV certification, suitable for pharmaceutical, cannabis, food & beverage, and cosmetic manufacturing.
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“Laboratory in Name Only” The LSP-600 ultrasonic processor is the largest, most robust, and versatile laboratory unit on the market today. It ensures optimal value for your equipment investment by offering both R&D functionalities along with light production capabilities. Configurations shown: LSP-600 Flow-Through Configuration; LSP-600 Flow-Through Configuration (side view); LSP-600 Batch Configuration (front view); LSP-600 Batch Configuration (side view); LSP-600 Air-Cooled Piezoelectric Transducer (ACT-500); LSP-600 Reactor Chamber; LSP-600 Full-Wave Barbel Horn (FBH, 21 mm tip diameter); LSP-600 Conventional Horn (CH, 12.7 mm tip diameter, optional); LSP-600 Flow-Through Configuration Components; LSP-600 Flow-Through Configuration (rendering); LSP-600 Batch Configuration with 80 ml Beaker (rendering); LSP-600 Flow-Through Configuration Schematic; LSP-600 Batch Configuration Schematic; LSP-600 in Sound Enclosure. The LSP-600 is a flexible laboratory ultrasonic processor designed to handle test batches with ease while providing the scale-up benchmark for larger production units. Engineered to streamline the transition from R&D to commercialization, the LSP-600 is reliable, flexible, and user-friendly. LSP-600 Features at a Glance: - Patented Barbell Horn®-based design capable of generating high amplitudes with broad amplitude control. - Two configurations: batch and flow-through. Typical processing volumes range from 15 mL to 2 L. - Portable, mobile, and compact, while consistently delivering powerful results. - Equipped with state-of-the-art components and accessories, including the NRE-30 sound enclosure, flow-through storage/mixing vessel with continuous stirring, and precise temperature control. - Capable of processing a wide range of liquids, including materials with high solids content and broad viscosity ranges. - Delivered worldwide and mostly pre-assembled for seamless integration into your lab. - Supported by ISM’s customer support team and detailed documentation to help users develop laboratory processes and scale them up. - Built with cGMP compliance in mind and used worldwide to develop formulations, conduct research studies, and support clinical trials. MAIN COMPONENTS Ultrasonic generator (600 W) - Input voltage: 100 Vac – 240 Vac @ 50/60 Hz - Rated current: 10 Amps max. - Output characteristics: 600 W (max.), 20 +/- 1 kHz (max.) - Additional features: continuous resonance frequency lock, automatic power adjustment, fine amplitude adjustment and lock (20 – 100 %), real-time monitoring of output power and frequency, optional external control, optional pulsed operation. Air-cooled piezoelectric transducer (ACT-22-LSP) - Output characteristics: amplitude — 22 microns (max.), frequency — 20 (+/- 1) kHz, power — 600 W (max.) Full-wave Barbell Horn® (FBH, 21 mm tip diameter) - Output characteristics: amplitude — 115 μm (max), frequency — 20 (+/- 1) kHz, power — 600 W (max.) OPTIONAL ACCESSORIES - Flow-through reactor chamber (flow cell, 1/2″ tri-clamp inlet and outlet, cooling jacket) - Conventional horn (CH, 12.7 mm tip diameter, amplitude — 113 microns (max.)) - Support stand with clamp holders - Noise reduction ear muffs - Sound enclosure - Magnetic stirrer with hotplate - 2 L process vessel - Peristaltic pump - Air blower - Water chiller - Glass beaker - NanoStabilizers® - Flow-through filters ADDITIONAL INFORMATION Materials of wetted parts: - Reactor chamber— 316 stainless steel. Food compatible. - Horns (FBH, CH, microtips)— Ti6Al4V. Food compatible. - Gaskets— Buna-N or Teflon. Food compatible. - O-rings— Buna-N. Food compatible. Noise level: - 103 – 106 dBa at 2′ away. Noise reducing earmuffs or sound enclosure required. Capacity - 15 ml – 100 ml—with CH (batch mode) - 100 ml – 500 ml—with FBH (batch mode) - 500 ml – 2 L—with FBH + reactor chamber (flow-through mode). Productivity rates - Productivity rates are highly dependent on the nature of each process and range from about 200 mL/h for challenging tasks (e.g., top-down nanocrystallization of active pharmaceutical compounds) to over 10 L/h for fast processes (e.g., degassing, deagglomeration). Frequently Asked Questions What is the LSP-600 ultrasonic processor used for? The LSP-600 is ISM’s laboratory-scale ultrasonic processor designed for feasibility testing, R&D, and process optimization. It is used for nanoemulsion formulation, extraction and cell disruption, degassing, dispersing and deagglomeration, and nano-crystallization at lab scale. It handles liquid volumes from 15 mL to 2 L and operates in both batch and flow-through configurations. What makes the LSP-600 different from a standard lab sonicator? Unlike conventional lab sonicators, the LSP-600 uses ISM’s patented Barbell Horn® Ultrasonic Technology (BHUT), which generates significantly higher ultrasonic amplitudes (up to 100 microns) than standard probes. It is also engineered for direct scale-up — any process developed on the LSP-600 can be transferred to the BSP-1200 or ISP-3600 without re-optimization. What is the processing capacity of the LSP-600? The LSP-600 handles 15 mL to 100 mL in batch mode with the Conventional Horn (CH), 100 mL to 500 mL in batch mode with the Full-Wave Barbell Horn (FBH), and 500 mL to 2 L in flow-through mode. Productivity rates range from approximately 200 mL/h for demanding tasks like pharmaceutical nanocrystallization, up to 10+ L/h for fast processes like degassing. Is the LSP-600 globally compliant? The LSP-600 is built with global compliance in mind. All wetted parts — 316 stainless steel reactor chamber, Ti6Al4V titanium horns, and Buna-N or Teflon gaskets — are food compatible. It carries CE and TÜV certification and is used globally in pharmaceutical research studies and various R&D trials. Can the LSP-600 scale up to production? Yes. The LSP-600 is specifically designed as the first step in ISM’s scale-up pathway: LSP-600 (lab) → BSP-1200 (bench) → ISP-3600 (industrial). Because all three processors use the same BHUT technology, process parameters developed on the LSP-600 transfer directly — with no loss in amplitude, processing conditions, or result reproducibility.
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The BSP-1200 ultrasonic liquid processor is designed for procedure optimization and medium-scale production. It is capable of continuous 24/7 operation and can handle unlimited liquid volumes. The BSP-1200 ultrasonic liquid processor comes standard with: 1200 W ultrasonic generator, water-cooled transducer, half-wave Barbell Horn®, flow-through reactor chamber (flow cell), heavy-duty support stand, spanner wrench set, and noise reduction ear muffs. Optional items include: full-wave Barbell Horn®, storage/mixing tank with integrated mixer, peristaltic pump, water chiller, magnetic stirrer with hotplate, jacketed beaker, NanoStabilizers®, and filters. The BSP-1200 processor can be used in batch and flow-through configurations. The BSP-1200 processor utilizes patented Barbell Horn® Ultrasonic Technology (BHUT), which makes it possible to generate extremely high ultrasonic amplitudes at any scale of operation. By upgrading to our larger BHUT-based unit, the ISP-3000, any process optimized with the BSP-1200 can be directly scaled-up to an industrial production environment, while maintaining the same processing conditions and reproducible results. MAIN COMPONENTS: - Ultrasonic generator (1200 W): Input voltage: 100 Vac – 240 Vac @ 50/60 Hz; Rated current: 20 A max. 10 A max.; Output characteristics: 1200 W (max.), 20 (+/- 1) kHz; Additional features: continuous resonance frequency lock, automatic power adjustment, fine amplitude adjustment and lock (20 – 100 %), real-time monitoring of output power and frequency, optional external control, optional pulsed operation. - Water-cooled piezoelectric transducer (SWCT-1200): Output Characteristics: amplitude — 24 μm (max.), frequency — 20 (+/- 1) kHz, power — 1200 W (max.) - Half-Wave Barbell Half-Wave Horn® (HBHB, 30 mm tip diameter): Output characteristics: amplitude — 94 μm (max.), frequency — 20 (+/- 1) kHz, power — 1200 W (max.) - Flow-through reactor chamber (flow cell): Features: 1/2″ tri-clamp inlet and outlet, cooling jacket with valved quick-disconnects. OPTIONAL ACCESSORIES: - Full-wave Barbell Horn® (FBH, 35 mm tip diameter, amplitude — 97 μm (max.)) - Half-Wave Barbell Horn® (HBH, 32 mm tip diameter, amplitude — 94 μm (max.)) - Support stand with clamp holders - Storage/mixing tank with integrated mixer - Peristaltic pump - Water chiller - Magnetic stirrer with hotplate - Stainless steel jacketed beaker - NanoStabilizers® - Flow-through filters - Noise reduction ear muffs - Sound enclosure ADDITIONAL INFORMATION: - Materials of wetted parts: Reactor chamber — 316 Stainless Steel. Food compatible. Horns (HBHB, FBH, HBH) — Ti6Al4V. Food compatible. Gaskets — Buna-N or Teflon. Food compatible. O-rings — Buna-N. Food compatible. - Noise level: 103 – 106 dBa at 2′ away. Noise reducing earmuffs or sound enclosure required. - Capacity: 500 ml – 2 L — with FBH (batch mode); 1 L – unlimited — with HBH + reactor chamber (flow-through mode) - Productivity rates: Productivity rates are highly dependent on the nature of each process and range from about 1 L/h for challenging tasks (e.g., top-down nanocrystallization of active pharmaceutical compounds) to over 50 L/h for fast processes (e.g., degassing, deagglomeration). 5 times faster processing than with the LSP-600 What is the BSP-1200 ultrasonic processor used for? The BSP-1200 is ISM’s 1200W bench-scale ultrasonic liquid processor designed for procedure optimization and medium-scale production. It handles nanoemulsion production, extraction and cell disruption, degassing and deaeration, dispersing and deagglomeration, and nano-crystallization. It operates continuously 24/7 in both batch (500 mL to 2 L) and flow-through (1 L to unlimited) configurations. What is the difference between the BSP-1200 and the LSP-600? The BSP-1200 is 5x faster than the LSP-600 and is designed for medium-scale production and continuous 24/7 operation, while the LSP-600 is optimized for lab-scale feasibility testing. Both use ISM’s patented Barbell Horn® Ultrasonic Technology, meaning any process developed on the LSP-600 transfers directly to the BSP-1200 without re-optimization. The BSP-1200 has ISM’s patented water cooled transducer which enables it to run continuously in the flow though configuration. Can the BSP-1200 be scaled up to industrial production? Yes. The BSP-1200 is the middle step in ISM’s scale-up path: LSP-600 (lab) → BSP-1200 (bench) → ISP-3600 (industrial). Because all three processors use the same BHUT technology, processes optimized on the BSP-1200 scale directly to the ISP-3600 while maintaining the same amplitudes, processing conditions, and reproducible results. What is the flow rate and processing capacity of the BSP-1200? In batch mode with the FBH horn, the BSP-1200 handles 500 mL to 2 L. In flow-through mode, it handles 1 L to unlimited volume. Productivity rates range from approximately 1 L/h for demanding tasks like pharmaceutical nanocrystallization, up to 50+ L/h for fast processes such as degassing or deagglomeration. Is the BSP-1200 suitable for pharmaceutical and food applications? Yes. All wetted parts are food compatible: 316 stainless steel reactor chamber, Ti6Al4V titanium horns (HBHB, FBH, HBH), and Buna-N or Teflon gaskets. The system carries CE and TÜV certification and is used in pharmaceutical, nutraceutical, cannabis, food & beverage, and cosmetic manufacturing.
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