RAM5 Pharma Continuous

By Resodyn Acoustic Mixers, Inc.

Resodyn Acoustic Mixers' production scale pharmaceutical mixer, the RAM5 Pharma Continuous, brings the awesome power of ResonantAcoustic® Mixing to larger scale to drastically increase productivity and expand capabilities. Built on flexible and universal processing capabilities, the RAM5 Pharma delivers exceptional RSD (Relative Standard Deviation) results, improved efficiency with rapid mixing and dispersion times, and new product opportunities at a larger payload capacity for RAM batch and continuous systems. Each RAM5 Pharma configuration matches the right processing functions with critical processing demands and exceeds the required performance beyond traditional technologies. Need a custom solution? All mixers can be customized for unique automations and applications. Pharmaceutical-Grade Performance at Production Scale The RAM 5 Pharma is purpose-built for pharmaceutical manufacturers who have outgrown bench-scale development and need the same mixing quality, content uniformity, and process reproducibility they saw in R&D. Since the RAM process is consistent across scales, the transition from R&D to production is seamless, unlike conventional mixing equipment. The RAM5 Pharma mixer creates enormous quantities of products. The flexibility of vessel size and shape allows for a rapid change in inputs and outputs. The enclosed structure allows for easy cleaning and sanitization. Key Processing Capabilities - Processes up to 80 lb (36 kg) per batch - Handles solids, powders, liquids, gases, and viscous materials - Supports milling, grinding, sieving, and coating (spray or dry) - Enables temperature control - Offers vacuum processing - Provides real-time monitoring and downloadable data for analysis - Stores up to 100 recipes for repeatable operations Key Advantages - 10–100x faster processing compared to traditional mixers - Highly repeatable results for consistent product quality - Direct scalability across the RAM product line - Exceptional ingredient distribution - Proven performance across global industries and applications - Variety of certifications available General Model RAM5 Pharma Technology ResonantAcoustic® Mixing Intended Use Batch Mixing of Pharmaceutical Materials Unit Dimensions 72'' H x 80'' W x 60'' D (182.9cm x 203.2cm x 154.2 cm) Unit Weight 8,000 lb (3629 kg) Country of Origin USA Certifications Available CE, UL, CFR 21 Part 11 Operating Specifications Maximum Payload Capacity 80 lb or 5 gallons (36 kg or 21 L) Compatible Materials Solids, Liquids, Pastes, High Viscosity Max Vessel Acceleration 100g at approximately 60 Hz Max Operating db < 70 db at 3’ Included Vessel Holder Assembly Application Specific Included Vessels Application Specific Control Specifications Human Machine Interface Full Color Touch Screen Operating System RAMWare™ Programable Mix Recipe Storage Yes Data Logging Yes Remote Operation Optional Control Features Up to 100 stored recipes, live monitoring, acceleration control Power Specifications Required Voltage 460 VAC / 3 Phase Documents - RAM5 Product Data Sheet Accessories The RAM5 Pharma will be configured exactly how you need. - Vacuum System - Jacketed Vessel System - Machine Chiller GMP and Contamination Free RAM uses vibrational energy instead of impellers or blades, and mixing occurs in sealed containers, minimizing cross-contamination, exposure risks, and reducing cleaning validation burdens — all crucial for GMP compliance. This bladeless, closed-system approach is not simply a convenience — for pharmaceutical manufacturers, it is a critical compliance and safety advantage that streamlines regulatory approval and reduces the time and cost associated with cleaning validation between product runs. RAM ensures uniform distribution of active pharmaceutical ingredients (APIs) even at low concentrations — such as below 1% — which helps maintain dose accuracy and content uniformity, critical for tablet and capsule formulations. Comprehensive Processing Capabilities Key processing capabilities include mixing and processing 80 lbs (36 kg) or more of any combination of solids and powders from nano-scale up, liquids and gases, and viscous and slurry materials, as well as coating, milling, and grinding processes, all with onboard control of processing accessories. The RAM5 Pharma is available with a full menu of processing options including temperature monitoring and control and mixing under vacuum. Standard functions include recipe development and retention, real-time parameter monitoring and recording, 100% processing data retention, multiple operator security levels, and multiple mixing vessel options. The system supports up to 80 lbs of mix capacity in extendable 5-gallon mixing vessels with application-specific vessel options. Proven in the World's Top Pharmaceutical Operations From the world's top pharmaceutical companies to international manufacturers and global tech giants, Resodyn Acoustic Mixer installations in over 40 countries are in use today, all sharing a single, powerful technology platform. The RAM5 Pharma represents that platform at its most powerful production-ready pharmaceutical configuration — delivering the speed, uniformity, and traceability demanded by modern drug manufacturing. Real-world impact is well documented. One pharmaceutical manufacturer reported challenges mixing a viscous, 10,000 cP solids-loaded transdermal cream consisting of water, excipient, API, and a sticky acrylate adhesive — a process that previously required multiple material addition steps and up to eight hours with an overhead stirrer. With a Resodyn RAM system, that mix was completed in just over two minutes. What is the RAM5 Pharma used for? The RAM5 Pharma Continuous is used for high-performance mixing and processing of a wide range of pharmaceutical materials, making it ideal for continuous large-scale production. What types of materials can the RAM5 Pharma process? The RAM 5 Pharma is designed to handle a very wide range of materials. Its key processing capabilities include mixing and processing any combination of solids/powders (from nano-scale and up), liquids/gases, and viscous/slurry materials, as well as coating, milling, and grinding processes. More specifically, RAM technology can efficiently mix virtually any combination of materials, processing them at nearly any particle size or behavior. Whether cohesive, agglomerated, nano-scale, or temperature-sensitive, a RAM mixer can control temperatures, apply vacuum, dry or spray-coat one particle on another, and effectively process any combination of powders, liquids, and high-viscosity materials. This includes liquids, pastes, and powders ranging from nano sizes to large particles, as well as highly viscous materials. In summary, the RAM 5 Pharma can process: - Solids & Powders — from nano-scale particles up to large particle sizes - Liquids & Gases - Viscous & Slurry materials - Cohesive or agglomerated materials - Temperature-sensitive materials (with temperature monitoring and control) - Pastes It can also perform coating, milling, and grinding processes, and optionally operate under vacuum for additional processing flexibility. What is the maximum batch capacity of the RAM5 Pharma? The standard capacity is rated at 80 lbs (36 kg). But this is not the whole story. Capacity is affected by the material itself and its rheological properties, by the acceleration at which you are processing, and even the weight of your container. Your capacity could be significantly higher or lower than 80 lbs (36 kg). Speak to your sales representative about your material and schedule a mix test for an accurate capacity based on your application details. How does acoustic mixing differ from traditional mixing methods? Acoustic mixing is the proven method of superior mixing and processing. It is bladeless, and is driven by vertical oscillation of the mix vessel at ~60 Hz and acceleration up to 100 g. Because the machine operates at resonance, it is energy efficient. The high energy motion drives mixing energy throughout the mix vessel for rapid and homogenous results beyond what conventional mixing can achieve. Traditional mixing methods vary, but generally rely on spinning paddles, tumbling vessels, or kneading action. Each method has significant limitations due to uneven energy distribution, excessive heat generation, slow processing, and material segregation. Simple mixing applications may achieve a suitable result, but the advanced processing needs commonly found in energetics, pharmaceuticals, advanced materials, batteries, additive manufacturing, and complex chemistries are often underserved by traditional mixing and processing methods. RAM is the processing technology that repeatedly solves the most difficult mixing, milling, coating, and chemical reaction challenges. What options are there for a RAM5 Pharma? Vacuum, temperature, various certifications