Scalable automation solutions ranging from feeding only systems to fully walk-away cell culture. Built for Next-Gen Cell Culture The Cellmatic is a fully automated cell culture system that handles your entire cell culture workflow continuously, from feeding and imaging to passaging and plating, without manual intervention. Define your protocol, load your cells, and walk away. The system manages the rest, around the clock, with consistency and reproducibility across every run. Designed for everything from routine cell line maintenance to complex, month-long iPSC differentiation protocols, the Cellmatic scales to your throughput and adapts to your workflow. Truly Walk-Away Cell Culture Load your cells, define your protocol, and step back — the system runs 24/7, unattended Many Cell Lines in Parallel Dynamic and versatile scheduler with flexible reagent handling supports 50+ cell lines in culture at once Built to Stay Sterile HEPA filtration, positive pressure access points, and hydrogen peroxide vapor sterilization Key Features Fully Automated Cell Culture Workflow: Automate the entire cell culture process, including feeding, splitting, expansion, plating, and differentiation, freeing researchers to focus on science instead of manual execution. High-Capacity Plate Handling: Each Incubator can support up to 200 SBS-format plates (1- to 384-well formats), enabling parallel processing of multiple cell lines and high-throughput experiments simultaneously. Intelligent Scheduling and Parallel Processing: An advanced scheduler allows multiple users and protocols to run simultaneously, automatically interweaving tasks without scripting or programming. Versatile Application Support: Supports stem cell differentiation, cell line development, high-throughput plating, permeability assays, and more — all on a single platform. Smart Liquid Handling with Minimal Waste: Each Cold Dispense unit can support 5 media solutions in a sterile, refrigerated environment. Low dead volumes (500 µL) and reusable tips minimize reagent waste and running cost. Integrated Cold Storage System: Provides robotic-access refrigerated storage for up to 96 SBS deep-well blocks, supporting large-scale reagent management in automated workflows. Automated Labware Handling with Stack®: The Integrated Stack robotic arm moves plates and labware between subsystems inside the sterile enclosure, coordinated automatically by the Cellmatic scheduler, eliminating manual handling and reducing contamination risk. Advanced Environmental and Contamination Control: HEPA filtration, hydrogen peroxide vapor sterilization, UV, and fully enclosed, CO₂, temperature, and humidity controlled Incubators maintain optimal, sterile growth conditions throughout operation. Intuitive, Web-Based Software: User-friendly, no-code interface with real-time monitoring, scheduling, and data export. Access the system and receive alerts from anywhere via web-based software. Which Cellmatic is Right for Your Lab? Full Cellmatic System Complete 24/7 passaging and feeding of cells Everything in the Feeding System Media Warmer Confluency Imager Labware Storage Optional add-ons BSC2 Enclosure for RX and FLO i8 PD Additional Incubator Centrifuge Capper/Decapper Custom Integrations Available From deep-freeze/thaw workflows enabled through third-party device integration to broader automation customization, the Cellmatic platform can be tailored to fit your laboratory’s specific process needs. In addition to standard configurations, custom integrations are available to support unique applications, specialized instruments, and evolving automation requirements. Our team works with labs to adapt the system around their workflow requirements, helping create an automation solution that fits today’s needs while supporting future expansion. Focus on Your Research. Let Cellmatic Handle the Rest The Cellmatic system executes feeding, splitting, and plate handling continuously, 24/7, with no interruption. Load your starting cells, define your protocol, and walk away. Continuous 24/7 cell culture maintenance, freeing researchers to focus on science rather than manual upkeep Replace flasks with SBS-Format plates for simpler expansion and parallel handling of multiple cell lines Flexible storage capacity to match your needs. Start with a single 200 plate capacity Incubator, or add more as your throughput increases; your choice of plate density from single-well up to 384-well Define cell maintenance and assay plate schedules through a single no-code scheduling interface, adaptable to any cell culture application or protocol Web-based access from anywhere, with email and text alerts for real-time system notifications Maintain Several Cell Lines with Intelligent Scheduling The Cellmatic scheduler allows multiple users and groups to run protocols for different cell lines simultaneously. The scheduling automatically interweaves tasks to maximize the throughput without scripting, programming, or manual coordination required from the end user. Versatile for a Broad Range of Scientific Workflows Stem Cell Differentiation Automate week and month long protocols with thoughtful management of expensive reagents Cell Line Development Pick colonies and propagate forward from 384- and 96-well plates Routine Maintenance and Expansion Continuously feed, image, and passage cell lines with extensive data record keeping Organoid Culture and Maintenance Gentle media exchanges and imaging support long-term growth Multi-well Plating for HT Screens Dispense cells into 384- and 96-well plates at user defined cell number Permeability Assays with Transwell Plates Feed and culture cells in transwell plates for your permeability assays Immunology Studies with PBMCs Differentiate and mature blood cells for immunological assays Save Time and Reagents with Smart Liquid Handling The system supports a wide range of reagents across two dedicated refrigerated units. The Cellmatic Cold Dispense stores bulk reagents in up to five 1 L bottles or 5 L media bags and automatically dispenses them into reservoirs directly within the refrigerated chamber, eliminating long tubing runs and the need to prime expensive reagents. The Cellmatic Cold Store provides cold storage for specialized reagents held in 96 deep-well blocks; when needed, these are automatically added to the base media to prepare the complete culture reagent on demand. Dispensed media is warmed before use with your cell culture plates. With capacity for up to 3 weeks of media storage and on-demand premixing for reagents with short expiration dates, the system runs extended workflows with minimal user intervention. Precise, Enclosed Labware Handling with the Formulatrix Stack The Formulatrix Stack handles all labware movement within the Cellmatic, transferring cell plates, reagent troughs, and tips between the Incubator, Reagent Exchanger (RX), FLO i8 PD, and confluency imager entirely within the sterile enclosure. Every transfer is coordinated automatically by the Cellmatic scheduler, with no user intervention required between steps. The Stack's enclosed arm architecture ensures consistent, spill-free handling of large-volume liquid troughs and delicate cell plates alike, maintaining the sterility of the system throughout every run. Advanced Technology Integrated into Every Subsystem 200-plates (multiple Incubators can be integrated together) with CO₂, temperature, and humidity controls 4°C refrigerated storage across two unit types: the Cellmatic Cold Dispense (up to 5 × 5 L bulk media bags) and the Cellmatic Cold Store (specialized reagents in 96 deep-well blocks), scalable with multiple units for up to 3 weeks of uninterrupted operation 8-channel liquid handler (FLO i8 PD), with independent z-axis control, dynamic liquid level detection, tilting deck, and choice of tip reuse or disposal RX, the automated plate washer, for media exchanges and high-throughput cell plating into multi-well plates Confluency imager capturing entire 96-well plate images in under 3 minutes Formulatrix Stack manages all labware transfers between subsystems, requiring no manual intervention Tightly controlled environment to reduce contamination — HEPA filters throughout, with access points maintained under positive air pressure Puroxia® hydrogen peroxide vapor generator enabling full system sterilization Efficient Cell Plating and Feeding with RX - Reduce Cost, Waste, and Time The RX is the automated plate washer built into the Cellmatic system. Reusable nozzles aspirate spent media and gently dispense fresh, warmed media, processing a full 96-well plate in under one minute. Optimized for delicate cells, the RX also plates cells into 96- and 384-well plates for assay generation. Excellent cell plating CVs by continually stirring the cell suspension during dispensing Improved cell viability through non-contact, sidewall dispensing Full 96-well plate aspirated and dispensed in under one minute Compatible with 1-, 4-, 8-, 96-, 384-well plates; optional configuration to support 6-well plates Low dead volume of <5 µL/well in a 96-well plate Reduce contamination risk with automated lidding and delidding Need to Expand Cell Lines? Let the Cellmatic Handle It. Load your starting cells, define the target cell number, and step back. The system handles the expansion automatically over the following days or weeks. The system uses one-well SBS format plates for cell expansion instead of flasks. It can output one well plate of expanded cells, pool multiple plates into a reservoir, or plate into high-density plates, depending on your needs. Run multiple cell line expansions in parallel, unattended. Intuitive, Web-Based Software Designed Specifically for Cell Culture Rather than scripting step by step aspirate and dispense sequences, users define the outcomes they want, specifying the trigger for splitting, imaging intervals, and passage ratio. The intuitive scheduler automatically interweaves all user requests. Results and analysis tools are displayed in a clear and structured layout with export tools for use in your own downstream analysis. Diagnostic routines run daily to confirm proper system operation. Purpose-Built for Stem Cell Differentiation Running a 30- to 60-day stem cell differentiation protocol? The Cellmatic handles your stem cells with precision and care. The 8-channel liquid handler manages growth factor additions on user-specified schedules. Phenotypic feedback — such as dendrite length from the high-resolution imager — can be used to direct protocols automatically. Cells are gently handled with minimal vibration throughout, and sidewall dispensing is used for all reagent additions. Protocols can be modified at any time, giving you full control. Protocol progress and results are visualized in the software dashboard throughout the run.
Automated Plate Washer A versatile automated plate washer designed to support a wide range of microplate formats and complex laboratory workflows. Volume Range Min: 20 µL Max: ∞ Self-Cleaning Up to 2 Cleaning Liquids Precision CV 5% @ 50 µL Reliable Plate Washer for a Wide Range of Applications and Microplate Formats The Reagent Exchanger (RX) is a versatile automated washer designed to support a wide range of microplate formats and complex laboratory workflows. It features integrated automation for delidding, plate tilting, dispensing, aspiration, and nozzle cleaning, delivering streamlined unattended operation. The RX easily integrates with automation platforms and supports robotic reagent loading to maximize efficiency, consistency, and workflow flexibility. Ease of Use Simplify liquid handling and reduce setup and operation time with the intuitive design and automated functionality Automation Friendly Integrate with automated systems and robotic arms to enhance workflow efficiency and minimize manual intervention Low Cost Consumables Reduce costs with affordable SBS-sized Automation Reagent Reservoirs and reusable tips that are washed between transfers Benefits Fast, Uniform Aspiration Across Plate Formats: Equipped with 96 nozzles for fast, precise, and uniform aspiration across 96- and 384-well plates, supporting high-throughput workflows with maximum efficiency Optimized Aspiration through Liquid Pooling: The tilting plate stage enables liquid pooling to optimize aspiration efficiency Preserve the Integrity of Loosely Adherent Cells: Non-contact side-wall dispensing minimizes fluid shear, preserving the integrity of loosely adherent cells Consistent Cell Dispensing with Maintained Suspension: Cells are consistently dispensed into 96- and 384-well plates by maintaining suspension with a stir bar Flexible Multi-Reagent Dispensing: Supports up to six dispensers, externally sourced or from Automation Reagent Reservoirs Contamination-Free Reusable Nozzles: Integrated cleaning stations ensure reusable aspirator and dispenser nozzles remain contamination-free Quick Reagent Changeover for Multi-Step Protocols: Easily swap reagent reservoirs for flexible, multi-reagent dispensing. Versatile loading options support both automatic and manual loading for seamless operation Seamless Compatibility with Lidded Microplates: Integrated delidder automatically removes and replaces lids, enabling uninterrupted processing of lidded microplates Efficient Transwell Plate Processing The RX uniquely enables efficient processing of transwell plates without the need to remove the insert, reducing manual handling and accelerating workflows while maintaining assay integrity. By automating the aspiration from the basolateral wells before the apical wells, the system effectively manages hydrostatic pressure and prevents the upward force that can delaminate or stress membrane-bound cell layers. This approach, combined with controlled sidewall dispensing into both the apical and basolateral chambers, ensures that delicate monolayers remain undisturbed even during high-throughput workflows. By repeating the dispensing sequence across columns, the RX eliminates variability from manual pipetting, reduces the risk of contamination, and delivers the high reproducibility required for sensitive transwell assays. Gentle Media Exchange for Sensitive Cells The RX performs controlled aspiration and gentle side-wall dispensing to protect sensitive, loosely adherent cells during media exchanges. This approach minimizes disturbance to the cell layer and reduces bubble formation and localized cell loss. To demonstrate this in practice, HEK-293T (loosely adherent) cells were cultured in 8-well plates and subjected to partial media exchange either manually or using the RX system. The RX performs controlled, gentle aspiration followed by slow side-wall dispensing to minimize disturbance to the cell layer. Cell detachment was quantified through pre- and post-feed imaging. The RX preserved sensitive HEK-293T cells significantly better than manual handling, resulting in only 4.9 ± 1.5% confluency loss, compared to 10.1 ± 2.7% with manual feeding. RX-fed cultures consistently recovered to ~80% confluence with uniform growth. In contrast, manually fed wells showed greater variability, localized cell loss, and bubble formation that interfered with imaging. RX media exchange reduces cell detachment Uniform, Reproducible Cell Seeding To evaluate seeding consistency at scale, HEK-293T and T47D cell suspensions were prepared in an Automation Reagent Reservoir with continuous stirring and dispensed into 96-well plates. After 6 hours of incubation, plates were imaged to assess well-to-well confluency and calculate plating uniformity (CV%). Manual controls were seeded using an 8-channel pipette with intermittent mixing. RX media exchange improves confluency, reduces bubbles and detachment Ensure Sterile Operation The RX supports sterile media exchange when integrated in an automated environment that provides VHP and/or HEPA control and validated decontamination workflows. In a representative sterile workflow, DMEM/F-12 media was dispensed using the RX integrated within the Cellmatic system following VHP sterilization and fluidic decontamination with 3% H₂O₂, followed by sterile water rinsing. Between media exchanges, fluid lines were flushed with 70% IPA and rinsed with sterile distilled water to minimize carryover. Daily monitoring of four 96-well plates demonstrated background signals consistently below 5%, indicating no detectable biological contamination. These results confirm that the RX cleaning and decontamination workflow supports reliable, routine sterile cell culture operations. Cell growth during multi-passage maintenance No Detectable Cross-Contamination The RX reduces inter-well carryover by using controlled aspiration/dispense behavior and optional nozzle washing during repeated media exchanges. To test this under repeated exchange conditions, two fluorescent iPSC lines (red and green) were seeded into defined columns of 96-well plates and subjected to multiple full media exchanges, performed both with and without nozzle washing. Imaging showed no inter-well fluorescence carryover, with colonies remaining confined to their original wells throughout the experiment. All colonies maintained expected phenotypes and expanded to confluence, demonstrating reliable multi-line co-culture without detectable cross-contamination. Cross-contamination assessment using fluorescent iPSC culture Common Applications Media Exchange Cell Dissociation Cell Plating Technical Specifications Liquid Handling and Labware Features - Dispense Volumes: 20 μL - Dispense Performance: 5% CV @ 50 μL - Aspiration: < 0.5 mL residual volume for 1-well; < 5 μL residual volume per well for 96-well - Labware Compatibility: 1-well, 4-well, 6-well, 8-well, 96-well, 96-Transwell, 384-well - Trough Capacity: 250 mL - Protocol Durations: Media Exchange < 30 sec (1-well plate full aspiration & dispense 15mL); Cell Plating < 30 sec (96-well plate 200 μL/well) User Interface Specifications - Browser / Web-based: Google Chrome Version 90 Electrical Requirements - 110-240 V, 50-60 Hz, 350 W Max, Standard or European Outlet Physical Dimensions - Width: 538 mm (21.2”) - Height: 425 mm (16.75”) - Depth: 391 mm (15.41”) - Weight: 25 kg (56.2 lbs) FAQs What is the Reagent Exchanger (RX)? The RX is an automated plate washer that performs media exchanges, aspiration, dispensing, plate delidding, tilting, and nozzle cleaning on microplates with minimal user intervention. What microplate formats does the RX support? The RX supports multiple SBS-format microplates, including 1-well, 4-well, 8-well, 96-well, 96-well transwell, and 384-well plates. It also supports lidded microplates courtesy of the integrated delidder. What is the aspiration and dispense performance of the RX? Aspiration achieves <0.5 mL residual volume in 1-well plates and <5 µL per well in 96-well plates. Dispense volumes are 20 µL, with ~5% CV and ~5% accuracy at 50 µL. What throughput can the users expect? The RX can perform a full media exchange in a 1-well plate (<30 seconds for aspiration + dispensing of ~15 mL) and cell plating into a 96-well plate at 200 µL per well in under 30 seconds. How does the RX minimize shear stress and protect sensitive adherent or loosely adherent cells? Angled dispense nozzles enable non-contact side-wall dispensing, which reduces turbulent liquid flow to delicate cell layers. Adjustable aspiration and dispense parameters like liquid flow rate and nozzle positioning minimizes cell detachment. What reagent or plate handling options are included? The RX features interchangeable reagent reservoirs and multiple external liquid connections (including waste, 2 cleaning liquids, and up to five externally plumbed dispense lines). A stirrer enables use of a stir bar in the Automation R
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Automated Cold Reagent Storage Designed for automated reagent preparation and delivery within temperature-controlled, integrated laboratory workflows. 1 mL/s Dispense Rate 4 % CV at 2 mL Dispense 0.1 mL Dispensing Accuracy ISO 5 Cleanroom Class - Dispensing Channel On-Demand Reagent Preparation Within a Controlled Cold Environment The Cellmatic Cold Dispense stores up to five reagent containers, either 1 L bottles or 5 L media bags, and automatically dispenses them into SBS-format reservoirs based on user-defined protocols. Reagent containers, plumbing lines, and the dispensing station are all housed within the refrigerated chamber, preserving reagent stability from storage through to delivery. Reservoirs are automatically delidded for dispensing and relidded before handoff, minimizing contamination risk and evaporation at every step. Right Reagent, Right Time Reagents dispensed on demand, eliminating manual loading and preventing warming on deck Automated Reservoir Preparation Multiple bulk reagents can be dispensed into a single reservoir, simplifying preparation for complex protocols Maintain Sterility at All Times The dispensing area is positively pressurized with HEPA filtration and meets ISO 5 cleanroom standards Key Features Software-Defined Reagent Protocols: Reagent compositions and volumes are defined entirely in the software, and the system dispenses automatically, eliminating manual premixing and enabling multiple users and protocols to run simultaneously. Bulk Reagent Storage: Stores up to five reagent containers (1 L bottles or 5 L media bags) within the refrigerated chamber. Reagents, plumbing lines, and the dispense station all remain at a controlled cold temperature throughout. Automated Delidding and Relidding: Reservoirs are automatically delidded inside the dispensing station, filled according to protocol, and relidded before exiting the system, reducing evaporation and protecting reagents from contamination. On-Board Reagent Mixing: Multiple reagents can be combined into a single reservoir within the system, enabling the automated preparation of custom reagent mixtures without manual intervention. ISO 5-Compliant Dispensing Chamber: The dispensing area is positively pressurized with HEPA filtration and meets ISO 5 cleanroom standards, with UV sterilization and internal HEPA air filtration to maintain a clean dispensing environment. Built-In CCTV Monitoring: An integrated camera inside the chamber enables remote monitoring of dispensing operations and system status without physical access. Precise Temperature Control: A variable-speed compressor with automatic defrost, soft-start control, and real-time pressure and temperature monitoring delivers ±0.2 °C temperature accuracy at a 4 °C setpoint. Ethernet and API Integration: Supports remote access, scheduling, and control by third-party automation platforms via Ethernet connectivity and an available software API. Automating Reagent Preparation From Storage to Handoff Rather than delivering reagents directly to a single instrument, the Cellmatic Cold Dispense prepares filled reservoirs that a robotic arm retrieves and transfers to any liquid handler in the workcell. This makes a single prepared reservoir available across the full system rather than tethering reagent delivery to a single instrument. Users define reagent compositions and dispensing schedules in software; the system handles the rest, including multi-reagent mixing into a single reservoir when the protocol requires it. The result is a hands-off preparation step that supports flexible experiment design and minimizes waste by dispensing only what is needed for each run. Clean, Stable, and Built for Continuous Operation The dispensing chamber is positively pressurized and conforms to ISO 5 cleanroom standards, with HEPA air filtration and UV sterilization maintaining a contamination-free environment throughout reagent preparation. Automated delidding and relidding of reservoirs further limit exposure of reagents to the ambient environment. A variable-speed compressor maintains ±0.2 °C accuracy at a 4 °C setpoint, with automatic defrost cycles, soft-start control, and real-time monitoring of suction and discharge line pressure and temperature. The modular design simplifies maintenance and minimizes downtime in automation environments requiring continuous operation. Part of the Cellmatic Cell Culture Automation Platform The Cellmatic Cold Dispense integrates natively with the Cellmatic Cold Store, Incubator, and automated plate washer, purpose-built modules that together cover the full cell culture workflow. Each component is also compatible with third-party robotic platforms, giving labs the flexibility to adopt Cellmatic components selectively within existing or custom workcell designs. Technical Specifications Electrical - Voltage: 100–240 VAC - Frequency: 50–60 Hz - Rated Power: 400 W Environmental - Operating Temperature: 18–25 °C - Operating Humidity: 0–60% RH - Temperature Control Accuracy: ±0.2 °C at 4 °C setpoint Reagent Capacity - 5 × 5 L media bags or 5 × 1 L bottles - Dispensing Channels: 5 Dispensing Performance - Dispensing Precision (CV): 4 % - Dispensing Accuracy: 0.1 mL - Minimum Dispensing Volume: 2 mL - Maximum Dispensing Volume: Unlimited Robotics Interface - Maximum robotic gripper entrance width: 200 mm Physical Dimensions - Width: 1006 mm (39.6'') - Height: 633 mm (24.9'') - Length: 805 mm (31.7'') - Weight: 156 kg (345 lb)
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High-Throuhput Liquid Dispenser Non-contact microdiaphragm dispensing across any volume, any reagent, and any well. Engineered for the precision and reproducibility that high-throughput workflows demand. Volume Range Min: 0.2 µL Max: ∞ Technology Micro-Diaphragm Pumps + Continuous Flow Precision CV <5% @ 0.2 µL Flexible and Precise Reagent Dispensing The Tempest is a consumable-free, non-contact, multipurpose liquid dispenser that leverages microdiaphragm pump and continuous flow chip technologies for high-throughput liquid dispensing. It allows researchers to dispense up to 12 different reagents simultaneously through 96 independently controlled outputs, delivering any volume of any reagent, into any well. Reduce Costs Miniaturize reactions with tipless dispensing Reproducible and Accurate Dispense volumes down to 200 nL at CV < 5% Versatile and Flexible Reagent dispensing for a broad range of applications Benefits Precision: Uses non-contact microfluidic technology, ensuring high accuracy and precision across a broad range of reagent types, including cells and beads. Speed: Dispense up to 12 reagents across 96 individually controlled nozzles in just seconds. e.g., 200 nL to a 96-well plate in 3 seconds; 1 μL to 384-well plate in 5 seconds. Fill a 96-deep-well plate with 2 mL per well in under 2 minutes. High Throughput: Stackers and barcode reader for automated high throughput screening workflows. Flexibility: The Tempest supports diverse inputs (pipette tips, tubes) and reagents (cells, beads, harsh chemicals), and is compatible with all SBS plates. Low Dead-Volume: Non-recoverable dead volume as low as 48 μL per chip. Cost Savings: Miniaturize assay design to reduce reagent usage, while tip-free, easy-to-clean components eliminate the need for consumables. Biosafety Cabinet Compatible: With its compact dimensions (555 mm x 309.67 mm x 266.56 mm), the Tempest can be used in various biosafety cabinets to accommodate workflows that require this level of safety. Automation-Friendly: Integrate with external systems effortlessly with a network API. Broad Range of Applications - High Throughput Screening (HTS) - Assay Development and Design of Experiment (DoE) - Enzyme-Linked Immunosorbent Assays (ELISA) - Polymerase Chain-reaction (PCR) Workflows - Real-time and Digital - Biochemical assay development and screening - Cell Culture and Bead-Based Assays - Next Generation Sequencing (NGS) - Library Preparation State-of-the-art Dispensing Technology At the core of each Tempest channel is a microdiaphragm pump that meters and dispenses discrete volumes of liquid. This valve cluster has two microdiaphragms (select either 200 nL and 1 μL, or 1 μL and 5 μL) that can fill and dispense as fast as 8 times per second. This technology is incredibly precise and can handle a wide range of viscosities. Key Features - High Precision - Low Volume Dispensing - Minimize Reagent Waste - Speed and Throughput - Keep Cells and Beads Suspended - Integrate with External Systems - Import CSV Templates - Incubation Re-Stack Option - No Consumables - Micro-diaphragm Technology Unparalleled Ease and Excellence The Tempest Liquid Dispenser utilizes patented microdiaphragm pump technology to allow researchers to maximize workflow efficiency from genomics to high-throughput screening workflows. Ease of Use: The Tempest software is extremely user-friendly allowing for easy experimental design. The standard gradient and backfill buttons make designing an experiment even easier and faster. Cost Savings: - Miniaturize assay design and reduce reagent usage - Save precious reagents through low dead volumes - Prevent failed experiments with clog-free dispensing technology - Intuitive software interface and experimental design - No Consumables. All components can be easily cleaned and re-used Stackers for Plate Storage and Incubation “Smart Batch-Delay” – facilitates incubation step by adding reagents, storing and cycling plates based on time-specific addition of reagents. The stackers are bidirectional, enabling plates to be cycled in from either stacker. Deep Well Block Dispensing and More TEMPEST supports nearly all SBS-footprint plates, including 24-, 96-, 384-, and 1536-well plates. Plate clearance able to accommodate dispensing into deep well blocks. Versatile Sample Control Dispense up to 12 different reagents simultaneously 12 microfluidic chips, each featuring eight independently-controlled dispensing nozzles. Automated re-circulation ensure quality data and minimize costly rework by keeping cells and beads in suspension. Variable Reagent Size Conserve reagents Return excess sample from the microfluidics back to the reagent container achieve a low dead-volume, 48 μL Reagents can be placed in nearly any container size and no pressurized bottles or special containers are needed Integrate and Customize Optional barcode scanner can be integrated to custom dispense unique reagent profiles based on each plates barcode The small instrument size and powerful automation interface enables the Tempest to be easily integrated with robotic plate handling arms, grippers and scheduling software. Hands-Free Maintenance Automated dual-solution wash cycle: Clean the entire fluid pathway without user intervention. The reverse fluid flow wash aspirates solution through the nozzle and forces any particles backward through increasingly larger channels for thorough, clog-free cleaning. Recirculate Small Recirculation Automated re-circulation ensures quality data and minimizes costly rework by keeping cells and beads in homogeneous suspension
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Sample Concentration - Buffer Exchange A fully automated, walk-away benchtop TFF system for sample concentration, diafiltration, buffer exchange, and desalting. Smarter Automation for Sample Concentration and Buffer Exchange The µPulse v4 is a fully automated walk-away benchtop TFF system for sample concentration and diafiltration, including buffer exchange and desalting, featuring improved consumables and enhanced process control to deliver gentle handling, high recovery at low volumes, and reproducible results while replacing manual centrifugation and dialysis with a smarter workflow. Key Benefits Faster Processing: Achieve permeate flow rates up to 4x faster than centrifugation while maintaining smooth, consistent flow across the membrane for reliable, reproducible filtration. Low Hold-Up Volume, Higher Recovery: Minimize sample loss with the next-generation µniPulse chip and confidently concentrate valuable samples to final volumes as low as 250 µL. Uninterrupted Buffer Exchange: Enable consistent diafiltration with unattended, automatic buffer transfer from an external reservoir. Walk Away: Set your parameters and let the µPulse handle concentration and buffer exchange automatically. Monitor progress remotely through a web-based interface and return only when your sample is ready. Flexible Operating Volumes: Process volumes from 0.5 to 100 mL, without compromising efficiency. Cleaner, Simpler Setup: Protect your sample from contamination throughout processing. An enclosed sample chamber and filter chip with integrated transfer tubing help eliminate contamination risk from setup to recovery. Fast Permeate flow rates up to 4x faster than centrifuges with dead-end filters Low Hold-Up Volume Ultra-low 0.25 mL hold-up volume with up to 100% recovery via automated recovery options Walk-Away System Load your samples, set your parameters, and let the system handle the rest Faster Sample Concentration with TFF Traditional centrifuge-based dead-end filtration pushes fluid directly into the membrane, creating a high concentration gradient at the membrane surface. As this layer builds, permeate flow can slow over time, and recovery may suffer. The µPulse moves the sample parallel to the membrane, keeping the pores open and enabling up to 4x faster filtration than dead-end filtration while preserving sample integrity. The dual-diaphragm pump and a larger membrane (~50-75% larger than typical dead-end devices) in the filter chip enable continuous flow and higher flux, so you can reach your target volume sooner and continue your research. The exact concentration rate depends on sample composition, starting volume, and membrane MWCO. Effortless Buffer Exchange and Desalting In addition to sample concentration, the µPulse supports automated diafiltration for buffer exchange and desalting with minimal hands-on effort. Once parameters are set, the system automatically manages buffer addition and removal, helping ensure consistent exchange without constant user intervention. Front-access centrifuge tubes simplify setup for both the sample and exchange buffer, while an external buffer reservoir with an integrated peristaltic pump enables uninterrupted diafiltration for larger buffer volumes, allowing true walk-away operation even for large diavolumes. Set Up Every Run with Confidence The µPulse v4 removes guesswork from setup with automatic chip tracking. The system identifies the membrane MWCO and chemistry as soon as a chip is installed, helping ensure the correct configuration is applied before each run. Chip usage and run history are tracked automatically, making it easier to maintain consistency across experiments, monitor chip lifetime, and standardize workflows across users. By reducing manual input and setup errors, the µPulse delivers more reproducible results with less day-to-day effort. Reliable Results Without Supervision Built-in controls keep every run predictable and your sample protected—without constant supervision. Precise TMP control: Electronically controlled feed and backpressure valves maintain a stable, application-specific TMP to protect sensitive samples and minimize membrane fouling. Accurate volume tracking: A high-sensitivity, low-volume load cell continuously monitors sample volume with ±0.02 mL accuracy, enabling confident endpoint control, preventing over-concentration, and ensuring buffer exchange reaches the desired extent. Monitor Your Run from Anywhere The µPulse features an intuitive web-based software interface that can be accessed directly on the system or from other devices on the same network. Setup is straightforward, allowing users to define starting and target volumes, concentration goals, and diafiltration or buffer exchange parameters with ease. Advanced settings are available to optimize performance for specific samples, while real-time run data lets users monitor progress remotely without repeated manual checks at the instrument. Consistent Filtration with Uniform Samples The µPulse includes a mixing cycle that helps keep samples uniform throughout the run. Recirculating the sample across the filtration membrane, it minimizes localized high concentrations, supporting more consistent filtration performance over time and helping protect overall sample quality.
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