By Korea Basic Science Institute
Support for national research in the field of structural biology based on the integrated operation of X-ray crystallography and Cryo-Electron Microscopy (Cryo-EM) Analysis of functions and mechanisms of action based on high-resolution three-dimensional structures of biomolecules Support for collaborative research in structure-based drug development and the bioindustry A unified X-ray and Cryo-EM platform for structural analysis Composed of expert personnel covering all areas of X-ray crystallography and Cryo-EM, with the capability to independently perform the entire process of structural research Structural Biology - Structural analysis using X-ray crystallography and Cryo-EM - Conducts structure- and mechanism-centered convergent research on various biomacromolecules including proteins, membrane proteins, protein–drug complexes, amyloids, and viruses X-ray Crystallography - Crystallization screening and optimization of proteins and protein–ligand complexes - Collection of X-ray diffraction data and structural interpretation at the atomic level - Bio-SAXS measurement and analysis Cryo-EM - Optimization of sample purification and grid preparation - Operation of high-performance Cryo-TEM and data acquisition - Single particle analysis, Cryo-electron tomography, helical reconstruction, subtomogram averaging, Micro-ED Data Analysis and Computational Structural Biology - Processing and management of large-scale structure-based data - Integrated interpretation based on atomic modeling and structure prediction - Operation of a high-performance computing environment
