SARomics Biostructures offers crystallization and X-ray structure determination of antibodies and antibody-antigen complexes, as well as high-resolution 3D epitope and paratope mapping. Our FastLane list of extracellular proteins for antibody-antigen complex crystallization, combined with our proximity to the 4th generation MAX IV synchrotron in Lund, ensures rapid delivery of results to our clients. All our studies also include biophysical characterization of the proteins in solution. SARomics Biostructures Antibody Structure Services: - Crystallization and 3D structure determination of antibodies and antibody-antigen complexes using X-ray crystallography. - High-resolution 3D paratope and epitope mapping, along with antibody mode of action analysis. Epitope definition to file a stronger IP. - FastLane proteins for antigen-antibody complex crystallization, with a turnaround time of a few weeks. - Fast access to BioMax and MicroMax beamlines at the 4th-generation synchrotron MAX IV in Lund. - Identification and analysis of conformational changes and allosteric effects during antibody:antigen complex formation. - Structure-based antibody engineering: affinity maturation, humanization, and generation of antibody-drug conjugates (ADCs). - Verified expertise in 3D epitope mapping, antibody and antibody-antigen complex crystallization, and structure analysis.
