SARomics Biostructures started as a company offering structural biology services, but over the years, it has expanded its platform to cover all aspects of structure-based drug design. The team has gained extensive experience in library screening, hit identification, and structure-based lead discovery. Based on our experience, we will discuss the main strategies for structure-based lead discovery and drug design. The choice of strategy depends on the available information, such as the three-dimensional structure of the drug target, known ligand structure (structures), and the availability of co-crystal structures of a ligand and target. Also, screening compound libraries and hit identification are crucial for any new lead discovery project.
