By Istituto Italiano di Tecnologia
Computational models predict RNA structures and functions of RNA-based systems, including toxicity forecasts for non-coding RNA variants from large cohort sequencing. Efforts also focus on designing aptamers, discovering binding sites, improving screenings of RNA-RNA and RNA-protein interactions, and experimentally determining RNA crystal and cryoEM structures in complex with small molecule modulators, especially for large RNAs. In the field of RNA–RNA interactions, RIME was developed as an AI-based tool capable of accurately predicting interacting RNAs, revealing the key role of repetitive sequences in gene regulation and nervous system development.
