By Nanotechnology Characterization Laboratory (NCL)
NCL efficacy studies that are conducted in rodents use a variety of tumor models to provide independent verification of collaborators' proof-of-concept studies, or add additional pharmacology endpoints to the original study. Efficacy of nanomaterial formulations can be tested using transgenic, syngeneic, xenograft, orthotopic, or metastatic models. NCL has many different cell lines available, and can usually obtain approval for other cell lines as required for a specific nanotechnology strategy. In collaboration with the Frederick National Lab's Small Animal Imaging Program, we also have the capability to assess imaging efficacy using bioluminescence and fluorescence imaging, CT, PET, MRI, and ultrasound.
