We are committed to providing high-level protein expression and purification services to produce quality recombinant proteins for our global customers through a flexible production scale model. With advanced workflow and technology, we work in partnership with our clients to meet their customized expression and purification needs and ensure high-throughput protein production, including recombinant antibodies for antibody drug conjugate development. Proteins are important biological macromolecules as they play key roles in almost every biological process of a living organism. Determining and understanding the 3D structure of a protein is essential for deciphering the mechanistic details about how a protein performs its activities. In small molecule drug discovery of any therapeutic area, it is a prerequisite to produce an enzymatically active recombinant protein that is equivalent to the native enzyme to understand its function/activity in an in-vitro setting. Towards this, the Structural Biology team at Jubilant Biosys provides: (A) enzymatically active recombinant soluble proteins, overexpressed from E. coli or baculovirus-insect cells or mammalian cells. (B) co-crystal structures of any soluble recombinant protein through X-ray crystallography using in-house X-ray diffraction facility, as well as accessing Australian Synchrotron beam. (C) stable cell lines that express protein-of-interest. This team has the experience of working with more than 20 pharmaceutical/biotech companies worldwide and made the following success stories. - Solved 11 novel structures and 5 fab complex structures. - Delivered > 250 co-crystal structures for ~40 different targets. - 7 publications in peer reviewed international journals. - Delivered > 300 proteins for assays from ~ 80 different targets. - Generated ~400 clones. Currently, the Structural Biology team has been focusing on biophysical platforms (SPR, Surface Plasmon Resonance using Pioneer FE system) to facilitate FBDD (Fragment Based Drug Discovery) support to clients.
Compiled from https://www.jubilantbiosys.com
