Not just since the Corona pandemic, the importance of protein crystallography in medical research has been obvious. With more than 2500 structures in the Protein Data Bank, BL14.1 is one of the most productive stations in Europe. Building on this success, higher throughput (roughly 500 crystals in 24 hours) capabilities by increasing the beamline flux significantly (x25) is desirable and achievable using a new double multilayer monochromator. The photon flux increase will be complemented with further automation efforts and meta data handling towards a fully automatic (unattended) data collection operation. Uniqueness: BL14.1ex opens avenues towards new crystallographic methods, such as the synchrotron based serial crystallography (SSX) method, which will be of the greatest importance for a future BESSY III MX-beamline. Partners: HZB