Plasma treatment is utilized in Quartz Crystal Microbalance with Dissipation monitoring (QCM-D) to clean and modify the surface of sensors, ensuring optimal conditions for studying biomolecular interactions. The process removes organic contaminants and introduces functional groups that enhance the immobilization of molecules on the sensor surface. This improves the sensitivity and accuracy of QCM-D measurements, making it easier to monitor changes in mass and viscoelastic properties of the adsorbed layers in real-time. Plasma treatment also helps maintain a stable and reproducible surface, crucial for consistent and reliable experimental results in QCM-D studies.