Salt screening is the process of co-crystallising a compound in the presence of counter-ions, with the aim of identifying novel solid forms that display improved performance characteristics and is applied to any molecule with one or more basic or acidic center. Salt forms often display improved performance characteristics over their free-form equivalent; dissolution rate, stability, and hygroscopicity can often be improved by employing a salt screening drug development strategy. Salt forms display polymorphism in the same way as free APIs. Polymorph screening is recommended on any novel salt forms, in order to fully understand their solid-form behaviour. Salt screening is an approach to quickly identify and assess the salt forms of an API and allows drug formulators to modify the physical properties of an API while preserving the benefits of a crystalline solid form. Salts of an API, often improve the APIs solubility, stability, crystallinity and can grow the solid-state portfolio of the API.
Compiled from https://www.jubilantbiosys.com
