Our biophysical fragment screening services utilize a proprietary library of MedChem-friendly low-molecular-weight compounds (around 1300) for WAC and NMR screening. Additionally, we have a kinase-focused fragment library designed explicitly for crystallographic fragment screening. These compounds are designed to cover diverse chemical spaces and are general-purpose. Customers can also use their own libraries for screening. Some characteristics of the library are listed below: - Designed to be general-purpose (not target-directed), covering diverse chemical space. - A focus on low-molecular-weight fragments (<220) - Solubility data (DMSO, water) are available for >80% of the fragments - Analytical data (LCMS, 1H-NMR) available for all fragments - Designed to be MedChem friendly (HBDs, HBAs, and ring count, ClogP, functional groups, etc.) - More than 90% commercially available, facilitating rapid SAR generation
