Mecwins AVAC Analyzer Counts Single Molecules to Reach Femtogram Sensitivity

25 October 2026. Mecwins has described how its AVAC technology enables ultrasensitive immunoassays that detect proteins down to the femtogram-per-millilitre range. The company published the explanation of the method on October 25, 2026.

Conventional immunoassays such as standard ELISA report an average signal across an entire sample. As target concentrations fall, that averaged signal sinks into background noise, and the limit of detection is reached before biologically relevant low levels are captured. Mecwins states this affects biomarkers that circulate at pg/mL or below, including many cytokines, neurological and cardiac markers, and early tumour-associated proteins.

The AVAC technology applies single-molecule counting optically. Target proteins are captured and labelled with plasmonic nanoparticles. Each nanoparticle is then detected and counted individually by dark-field micro-spectrophotometry. Because the readout is a direct, single-particle digital count, the AVAC Analyzer reaches sensitivities in the femtogram range while keeping a simple workflow, according to the company.

Mecwins lists oncology, cardiology, neurology, immunology and infectious disease among the fields where ultrasensitive detection is used. The company says quantifying a protein previously below the limit of detection opens new windows for discovery and, ultimately, for clinical decision-making.

Mecwins invites researchers and clinical programmes evaluating ultrasensitive protein detection to contact its team about applying AVAC.

Source: Mecwins news