Our lists of FastLane extracellular proteins prepared for co-crystallization with their specific antibodies further reduce time and costs for high-resolution 3D epitope mapping. These proteins have already been used in numerous projects to determine the structure of antibody-antigen complexes. The turnaround time for these complexes can be as short as just 3-4 weeks. FastLane™ Premium & FastLane™ Standard Extracellular Proteins ALB - Human albumin, HSA BSSL - Bile salt-activated lipase CD11b - Human Integrin alpha M CD28 - T-cell-specific surface glycoprotein CD28 CD47 - Leukocyte surface antigen CD47 CD137 - TNFRSF9, Tumor necrosis factor receptor superfamily member 9 GPVI - Platelet glycoprotein VI HER2 - Receptor protein-tyrosine kinase HER2 extracellular domain IL-4 - Recombinant Interleukin-4 IL-8 - Recombinant Interleukin-4, CXCL8 IL-13 - Recombinant Interleukin-13 IL-17A - Recombinant Interleukin-17A IL-23 - IL-23A, Interleukin-23, subunits alpha and beta NRP1 - Neuropilin-1 PD-1 - PDCD1, Programmed cell death 1 PD-L1 - PDL1, Programmed cell death 1 ligand 1 SARS CoV-2 RBD - Spike glycoprotein receptor-binding domain (SARS-CoV-2) TIM-3 - Hepatitis A virus cellular receptor 2, HAVCR2 TL1A - Tumor necrosis factor ligand superfamily member 15 TNF-alpha - Tumor necrosis factor
we offer our proprietary library of MedChem-friendly, low-molecular-weight fragments, designed to be general-purpose (non-target-directed), covering a diverse range of chemical space. Of course, customers’ libraries may also be used for screening.
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The ProPHECY™ in silico protein optimization software package is designed for quantitative structure-activity relationship (QSAR) analysis of protein modifications. It uses a unique algorithm that leverages experimentally determined protein parameters to predict amino acid replacements needed to create new protein or peptide variants. ProPHECY™ in silico protein and peptide optimization can be used in biotechnology and the design of biological drugs. Modifying and optimizing the amino acid sequence of a protein or peptide enables the creation of a model to understand its quantitative structure-activity relationships (QSAR). This knowledge can then be used to control and modify reactivity and other properties. Our software package, ProPHECY™, operates similarly to the well-known QSAR methodology used in small-molecule drug design.
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SARomics Biostructures offers a catalog of high-purity, crystallization-grade recombinant proteins for drug discovery. The proteins are expressed and purified to a high level in our protein lab. We have conducted biophysical characterizations and validated their suitability for crystallization and X-ray crystallography (please refer to our Knowledge pages for a discussion of the strategies employed in structure-based drug design). The recombinant proteins are suitable for use in various biophysical and biochemical assays and can be shipped to customers for drug discovery research purposes. By clicking on the respective entry below, you can download a product sheet with details of the purification and characterization of each protein. Crystallization-grade recombinant proteins The product sheets contain description, specification and quality control for each protein product. Please note that proteins are shipped frozen on dry ice.
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