SARomics Biostructures offers a catalog of high-purity, crystallization-grade recombinant proteins for drug discovery. The proteins are expressed and purified to a high level in our protein lab. We have conducted biophysical characterizations and validated their suitability for crystallization and X-ray crystallography (please refer to our Knowledge pages for a discussion of the strategies employed in structure-based drug design). The recombinant proteins are suitable for use in various biophysical and biochemical assays and can be shipped to customers for drug discovery research purposes. By clicking on the respective entry below, you can download a product sheet with details of the purification and characterization of each protein. Crystallization-grade recombinant proteins The product sheets contain description, specification and quality control for each protein product. Please note that proteins are shipped frozen on dry ice.
The ProPHECY™ in silico protein optimization software package is designed for quantitative structure-activity relationship (QSAR) analysis of protein modifications. It uses a unique algorithm that leverages experimentally determined protein parameters to predict amino acid replacements needed to create new protein or peptide variants. ProPHECY™ in silico protein and peptide optimization can be used in biotechnology and the design of biological drugs. Modifying and optimizing the amino acid sequence of a protein or peptide enables the creation of a model to understand its quantitative structure-activity relationships (QSAR). This knowledge can then be used to control and modify reactivity and other properties. Our software package, ProPHECY™, operates similarly to the well-known QSAR methodology used in small-molecule drug design.
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