Thin-piezoelectric-film technology is leaving the laboratory to become commercial PiezoMEMS Analyzer. Much thicker bulk capacitors are being embedded as actuators and sensors inside their own electronic circuitry. Multidisciplinary teams of mechanical, electrical, and reliability engineers now work alongside materials engineers to create new and novel devices. Classic engineering tools such as impulse response, impedance analysis, and resonance characterization must be integrated with traditional polarization, piezoelectric, pyroelectric, and magnetoelectric measurements. To control circuits containing embedded ferroic capacitors, asynchronous or semi-synchronous digital and analog functions must run independent-of or in-parallel-with crystal-clock-controlled ferroic measurements. Communication with embedded controllers and custom digital circuitry is critical. Together these requirements demand an extremely complex test environment. Radiant Technologies’ Precision PiezoMEMS Analyzer integrates digital, analog, and communications circuit functions with the existing non-linear materials measurement capabilities of the Precision Multiferroic Non-linear Materials Tester, all supervised by Radiant’s Vision programmable test environment. The PiezoMEMS Analyzer not only measures piezoelectric properties of actuator and sensor elements of a commercial product, it will communicate with the product’s electronic logic, talk to embedded microprocessors, supply asynchronous voltages and pulses, and measure sensor frequencies.

Cryo-electron microscopy (cryo-EM) has taken enormous flight in recent years. Atomic level structural analysis of viruses and proteins derived by cryo-EM using SPA workflows requires high stability hardware and software. JEOL proudly announces its latest offering in cryo-TEMs to facilitate this development in cryo-EM with the CRYO ARM™ 200. The CRYO ARM™ 200 achieves unprecedented resolution and stability thus allowing for the automatic and unattended acquisition of image data for Single Particle Analysis. Automated specimen exchange system The system is composed of an autoloading specimen stage cooled to liquid nitrogen temperatures and a cryo-storage device for long-term storage of up to 12 frozen-hydrated specimens. Liquid nitrogen is automatically supplied to both the stage and storage system as required. The autoloader allows loading of retrieval of up to 4 grids at a time without impacting the remaining samples in the cryo-storage device. Specimens are stored and labeled using a unique system fully transparent to the operator. These unique capabilities enable beamline-like scheduling of microscopy. Cold field emission gun (Cold FEG) The cold FEG produces a high-brightness electron beam with a very small energy spread, thus offering high temporal coherency. In addition, spatial coherence is improved resulting in the CRYO ARM™ 200 achieving superior resolution and contrast compared any 200 kV cryo-TEM currently on the market. In-column energy filter (Omega filter) Equipped with an improved in-column energy filter (Omega filter), the CRYO ARM™ 200 acquires energy filtered images and energy loss spectra. Zero-loss imaging with the CRYO ARM™ 200 yields data with higher contrast due to reduced chromatic aberration. Automated image acquisition software for Single Particle Analysis The CRYO ARM™ 200 incorporates automated software for Single Particle Analysis (SPA) workflows called JADAS. This software allows for automated detection of holes on the specimen grid for automated, unattended acquisition of high-resolution images. Additionally, the CRYO ARM™ 200 is fully compatible with SerialEM (UC Boulder). Hole-free phase plate *1 The hole-free phase plate (HFPP) consist of a thin, continuous carbon film placed in the back focal plane of the objective lens, thus providing a substantial improvement in image contrast of frozen-hydrated specimen. Manufacturing of the HFPP uses a unique methodology resulting in robust and reliable performance at reasonable prices. Auto adjustment functions *2 Auto focus, auto coma-free alignment, auto parallel-beam illumination and other automated adjustments are available, enabling image acquisition under optimum conditions. *1: Optional unit. *2: Images acquired with the bottom mount camera are used.

The JEM-2100 Plus is a multipurpose 200kV LaB6 TEM that provides solutions for a wide range of applications from materials science to medical/biological studies, all at a low cost of ownership. Achieving superior performance through intuitive operation, the JEM-2100Plus advanced control system allows integration of STEM, EDS, and EELS as well as remote operation. For ease of use, the “TEM Center” software displays column controls, STEM operation, and camera operation compactly in a single screen. Operation is intuitive and uncomplicated. The operator can easily select a wide range of illumination modes at the touch of a button. To acquire images and diffraction patterns there is an optional JEOL-made bottom-mount camera called the “Matataki Flash” camera with a cutting-edge sCMOS sensor. The JEM-2100Plus features a high-stability goniometer stage specifically tuned for high tilt tomographic applications. An x/y piezo stage is an available option. The JEM-2100Plus has three independent condenser lenses, optimizing probe conditions for any given probe size for a variety of application such as EDX or NBD. This allows for improved analytical and diffraction capabilities giving quality results quickly and effortlessly. The patented JEOL Alpha Selector™ allows a user the selection of a variety of illumination conditions, ranging from full convergent beam to parallel illumination. The standard incorporation of the objective mini lens means that Lorentz microscopy is a standard feature of this microscope. A high contrast aperture is available for any choice of polepiece, allowing high contrast imaging and simultaneous EDS. The JEM-2100Plus offers a number of pumping options including full dry-pumped/turbo-pumped versions for lab environments that do not allow for oil-based or rotary pumps.

Transmission Electron Microscopes (TEM) of 120kV accelerating voltage are widely used in soft material fields such as biology and polymer. We developed the JEM-120i with the concept of "Compact", "Easy To Use", and "Expandable". With the new external appearance, this instrument has evolved into a useful tool that anyone can use easily, from operation to maintenance.

Customers who would like to produce translucent nanoemulsions of lipophilic (oil-soluble) bio-active compounds, such as cannabis extracts (a.k.a. water-soluble CBD and THC), vitamins, essential oils, terpenes, nutraceuticals and pharmaceuticals, but do not have the capability or desire to develop their own formulations and processing procedures can take advantage of our all-in-one NanoStabilizer®-LT. This proprietary blend of food-grade (GRAS) carrier oils, emulsifiers, and preservatives (all derived from natural sources) is designed to work with ISM laboratory, bench and industrial ultrasonic processors and comes with step-by-step processing instructions. NanoStabilizer®-LT has no taste of its own and makes it possible to easily and quickly produce highly translucent, permanently stable and fully water-compatible nanoemulsions with median droplet sizes in the range of 10 – 50 nanometers. Loaded with up to 50 mg/ml of bio-active ingredients, these nanoemulsions can be be easily sterilized by filtration and infused into a variety of water-based products (e.g., water, beer, tea, coffee, carbonated beverages, juices, gummies, edibles, topicals) without changing their physical appearance. They can also be used directly (e.g., as nasal and oral sprays or sublingual drops or strips).

Manufacturers that would like to produce their own water-soluble nanoemulsions of various mushroom extracts but do not have the capability or desire to develop formulations and processing procedures can take advantage of ISM’s All-In-One NanoStabilizer®-LSTM. This formulation comprises natural, food-grade carrier oils, emulsifiers, and humectants. It is designed to work with our laboratory, bench and industrial ultrasonic processors and comes with step-by-step processing instructions. NanoStabilizer®-LSTM is tasteless and makes it possible to easily and quickly produce permanently stable and fully water-compatible liquid and powdered nanoemulsions with median droplet sizes in the range of 60 – 300 nm (depending on mushroom extract type). Water-soluble powders prepared with this product reconstitute back into liquid nanoemulsions when mixed with water.

Companies that would like to produce their own water-soluble nanoemulsions of lipophilic (oil-soluble) bio-active compounds, such as cannabis extracts (a.k.a. water-soluble CBD, Delta 9, Delta 8 and Delta 10 THC, etc.), vitamins, essential oils, terpenes, nutraceuticals and pharmaceuticals, but do not have the capability or desire to develop formulations and processing procedures can take advantage of ISM’s All-In-One NanoStabilizer®-LSO. This proprietary blend of natural, organic, food-grade carrier oils, emulsifiers, and humectants is designed to work with our laboratory, bench and industrial ultrasonic processors and comes with step-by-step processing instructions. NanoStabilizer®-LSO is tasteless, provides bitter taste masking and makes it possible to easily and quickly produce permanently stable and fully water-compatible liquid and powdered nanoemulsions with median droplet sizes in the range of 150 – 200 nanometers. Water-soluble powders prepared with this product reconstitute back into liquid nanoemulsions upon contact with water.

The Reflection DHM series (DHM®-R1000, DHM®-R2100 and DHM®-R2200) are reflection configured holographic microscopes. They are ideal for measuring totally and partially reflecting objects. Their ability to work with low reflective interfaces (down to less than 1% reflectivity), make them ideal instruments for accurate optical topography measurements on a large variety of samples. With their high acquisition rate and ease of use, DHM® instruments allow rapid routine inspections, automated industrial quality control as well as innovative R&D applications, particularly for dynamic observations. There are three configurations available, defined by the number and combination of wavelengths: R-1000 series: single laser source R-2100 series: dual laser sources R-2200 series: three laser sources The reflection DHM® are compatible with the optional Stroboscopic module and the post-analysis software for MEMS analysis and Reflectometry analysis. Each DHM® can be delivered with its own structure to hold it, or as a head only, to be mounted on other structures or on production lines. The DHM® are compatible with a large range of optional motorized stages. Lyncée Tec has developed the DHM® technology from its invention to its maturity. It has the competence and flexibility to offer you customized and OEM systems.

The Form Talysurf® PGI Optics PRO contact profilometer, measures surface form & radius of optical components, from a large diameter lens with large SAG to small plastic lenses. Producing high accuracy measurements on spherical, aspherical, diffractive and fresnel lenses up to 300 mm diameter (single trace, no stitching). The system is capable of measuring both IR (infrared), visible substrates and mirror optics. These capabilities make the Form Talysurf® PGI Optics PRO the backbone of optical manufacturing.

The world’s fastest and most accurate automated system, for non-contact 3D small lens metrology. The LUPHOScan 75 HD brings laboratory level accuracy to high volume production. Consistently accurate results are achieved with a single click, enabling operators of any level to deliver fast detailed analysis. Unique benefits for both design and production - Automatically align optics - In as little as 45 seconds* - Faster measurement cycles with the Focal Point Pivot (FPP) technology - Up to 65% reduction in time* - Ultra high, repeatable accuracy - ≤ 30 nm PV (3σ) - Best available stability - Power variation < ± 15 nm (3σ), PV variation

Qnami ProteusQ is a complete quantum microscope system. It is the first scanning NV (nitrogen-vacancy) microscope for analyzing magnetic materials at the atomic scale. This microscope system comes with state-of-the-art electronics and software. Its flexible design allows for future adjustments and scaling, expansion, and capability upgrades. The proprietary technology of Qnami’s quantum microscope provides high-precision images for you to see directly the most subtle properties of your samples and the effect of microscopic changes in your design or fabrication process.

ProteusQ-LT table-top design offers a new approach to microscopy in cryogenic environments. Unprecedented accessibility and wide optical access simplify day to day operations. Table-top cryostat platform - Powered by Qinu - 2.5K base temperature - Ultra-low vibration levels Sample and probes - Compatible with QuantileverTM high resolution probe technology - Safe and fast probe and sample exchange mechanisms - Top and later optical access with large fields of view SNVM - Optimized photon collection efficiency ensuring uT sensitivity - Large scan ranges - LabQ software interface (same as ProteusQ)

Formvar and Carbon support films consist of a thin layer of Carbon evaporated onto a Formvar film. This offers improved conductive properties in comparison to standard Formvar films. These are typically thicker support films which may compromise high resolution imaging but will return a stronger and more stable film. The Formvar layer is typically approx.10nm thick with a thin (

Carbon only support films offer a thin, finely structured background support transparent to the electron beam and are particularly good for small nanoparticles and viruses which do not cluster or will not span the holes of a perforated film. Electrically and thermally conductive and provide image and specimen stability for high resolution imaging. The standard thickness of the Carbon films is approx. 10-20nm. Different combinations of grid meshes, pack sizes and film thicknesses are available on request.

Graphene support films coated onto either a 2000 mesh Copper TEM grid, Lacey Carbon film on 300 mesh Copper or Quantifoil 2μm support films. Graphene offers the thinnest film possible whilst also being more conductive than standard Carbon films provides minimal background noise and clearer images. Ideal for high resolution or nanoparticle imaging. Multi-Layer option available in 3 thickness groups with a maximum of 8 layers, as requested. Better than 75% Graphene coverage of TEM grid.

UltrAuFoil® films are a specialised Holey Gold sample supports make structure determination for challenging and small molecules easier. More conductive, with no differential contraction between the grid and the foil on plunge freezing, UltrAuFoil® Holey Gold supports crinkle and move less during irradiation resulting in improvements in image and data quality.

QUANTIFOIL® films are a specialised Holey Carbon film, approx. 10-12 nm thick, with a regular pattern of holes and spaces. These are used where Goldtomation of imaging and data collection are required, e.g. Cryo-EM of single particles and structural biology applications. QUANTIFOIL® films’ defined cirCopperlar holes tend to yield thinner, uNickelform layers of ice; improving sample distribution and reduced background Available in a range of patterns and grid types to suit user’s sample characteristics and imaging modality: Small holes for high-resolution SPA of protein complexes Larger holes and less carbon to maximise open viewing area for tomography and materials science More Carbon and fewer holes for on-grid cell growth

Graphene Oxide (GO) support films are one of the thinnest support films available. Flakes of GO lie across holes in a base support film to create an ultra-thin film making GO films ideal for imaging Carbon Nanoparticles where a continuous film is required but the Carbon support would result in low contrast. For good monolayer coverage we expect ~ 50-70% of the grid area to be covered with GO and up to 30% of that coverage to be monolayer. If a different thickness of GO is more suitable for your application please contact us for a quote. GO films are inherently hydrophilic and should not be plasma cleaned before use as this may damage the film. GO films also have higher heat and electrical conductivity than Carbon films.

Lacey Carbon support films are Holey films which have larger holes and very little Carbon between them, giving the film a web or lace like appearance. Offer a wider range of hole sizes and are more robust than Holey Carbon films so will withstand more rigorous sample pre-treatments. These films are ideal for analysis of larger particles, crystals and nano-wires which will span larger holes, providing background free imaging. Also ideal for coating with Graphene or Graphene Oxide films. Different combinations of grid meshes, pack sizes and film thicknesses are available on request.

Holey Carbon support films have a range of hole sizes distributed irregularly across a flat Carbon film. The smallest holes are often smaller than those found in Quantifoil™ Holey Carbon films. These can be controlled to some degree during the manufacturing process to meet individual requirements, offering a cost effective solution where a continuous Carbon film is not desirable. Ideal for viewing specimens without background support, especially suited for suspensions of viruses or nanoparticles. Different combinations of grid meshes, pack sizes and film thicknesses are available on request.