SARomics Biostructures offers crystallization and X-ray structure determination of antibodies and antibody-antigen complexes, as well as high-resolution 3D epitope and paratope mapping. Our FastLane list of extracellular proteins for antibody-antigen complex crystallization, combined with our proximity to the 4th generation MAX IV synchrotron in Lund, ensures rapid delivery of results to our clients. We also offer higher-order structure (HOS) analysis of biosimilars using X-ray crystallography and NMR spectroscopy. All our studies also include biophysical characterization of the proteins in solution. - Crystallization and 3D structure determination of antibodies and antibody-antigen complexes using X-ray crystallography. - High-resolution 3D paratope and epitope mapping, along with antibody mode of action analysis. Epitope definition to file a stronger IP. - FastLane proteins for antigen-antibody complex crystallization, with a turnaround time of a few weeks. - Fast access to BioMax and MicroMax beamlines at the 4th-generation synchrotron MAX IV in Lund. - Identification and analysis of conformational changes and allosteric effects during antibody:antigen complex formation. - Structure-based antibody engineering: affinity maturation, humanization, and generation of antibody-drug conjugates (ADCs). - Verified expertise in 3D epitope mapping, antibody and antibody-antigen complex crystallization, and structure analysis.
