NW
Chemical Synthesis & FormulationSynthesis & Production

Functional Modifications & Sequence Optimizations

By ATDBio

We offer a comprehensive range of modifications to enhance the functionality and performance of your oligonucleotides, including: - 3'-phosphate or 3'-inverse dT to prevent extension by DNA polymerase - 5'-phosphate for ligation in NGS library preparation - Biotin modifications for capture/enrichment applications - Amino linkers and click chemistry moieties for conjugation - LNAs to increase duplex stability and specificity - Abasic sites to reduce secondary structure - Spacers for flexibility and improved performance - Degenerate bases for detecting multiple sequence variants - Phosphorothioates for increased nuclease resistance - Epigenetic modifications for specialized applications