By Karlsruhe Nano Micro Facility (KNMF)
KNMFi Laboratory for Microscopy and Spectroscopy At CORREL, we integrate X-ray imaging (XRI), magnetic resonance imaging (MRI), and nuclear magnetic resonance (NMR) spectroscopy into a single platform, offering a unique correlative approach that combines multi-modal imaging and spectroscopy for sample analysis. CORREL facilitates the simultaneous acquisition of spatio-temporally resolved chemical information (NMR spectroscopy) and structural information (XRI, phase-sensitive XRI, MRI) from a single sample, across various length and time scales specific to each method. We recommend a preliminary consultation with our team on the following topics before initiating a project: 1. Sample concentration and/or quantity; 2. Sample size and additional experimental conditions (e.g., temperature, current/voltage, fluids in/out); 3. Sample phase; 4. Target nuclei to be analyzed; 5. Type of samples (e.g., low-absorbing, composite with similar characteristics, degradable, X-ray radiation-sensitive); 6. Process to be studied and temporal resolution; 7. Desired imaging resolution and contrast requirements. Details (CORREL) Liquid Gallium / Indium metal jet X-ray source “Excillum D2+” Bruker BioSpec 70/11 (7T MRI/MRS system) Features / Characteristics Bruker BioSpec 70/11 System - Field strength: 7.0 T - Bore diameter: 105 mm - Cylindrical homogeneity volume: Diameter x Length 30 x 60 mm - Homogeneity: peak-peak 4 ppm - Gradient strength: 740 mT/m RF Channels - 1H/19F - 12C, 7Li, 23Na (other nuclei are possible upon consultation) X-ray - Acceleration voltage up to 70 keV - 250 W max. electron beam power - X-ray spectrum with Ga Ka-Line at 9.24 keV and In Ka-Line at 24.2 keV - Source spot size: 20 µm vertical x 80 µm horizontal at 250 W; 10 µm x 10 µm at 10 W - Resolution in Computed Tomography (CT) imaging: 30 µm voxel size for centimetre size samples, 5 µm voxel size for below 2 mm sample size Typical measurement methods - MR imaging and NMR spectroscopy - Computed Tomography (CT) in about 3 h total exposure time - Radiography - Absorption / phase / darkfield contrast imaging using Talbot-Lau gratings - Hartmann-based multi-contrast spatial harmonic imaging with 250 ms time resolution Limitations/constraints - Maximum sample size ~30 mm Ø - Only non-ferro-magnetic materials in the magnet (if only XRI is needed, magnetic or large samples are possible)
