The Nuclear Magnetic Resonance (NMR) Facility offers state-of-the-art, solution-state NMR instrumentation to support chemistry and biomolecular research at Scripps Research and within the broader scientific community. In addition to routine spectroscopic services, the facility’s experienced staff implement advanced methodologies for high-resolution structural, dynamic and kinetic studies that enable a broad range of research programs. The NMR Facility houses a total of six NMR spectrometers; - Bruker AVIII HD 600 NMR spectrometer equipped with a 5 mm CPQCI (H-C-N-P) CryoProbe and a SampleCase-24 sample changer. This spectrometer also has a 1.7 mm CPTCI (H-C-N) CryoProbe. This probe can be installed upon requested for experiments on micro-gram scale compounds. - Bruker AVIII HD 600 NMR spectrometer equipped with a 5 mm CPDCH (C-H) CryoProbe. This CryoProbe provides high sensitivity for C-13 NMR experiments. - Bruker AV NEO 500 NMR spectrometer with a 5 mm BBFO Smart Probe and a SampleCase-24 sample changer. - Bruker AVIII 400 NMR spectrometer equipped with a 5 MM BBFO probe and a B-ACS 120 sample changer. - Bruker AV NEO 399 NMR spectrometer equipped with a 5 mm BBFO Smart Probe. All BBFO probes have the capabilities to perform NMR experiments on nuclei with resonance frequencies between Ag-109 and P-31, as well as H-1 and F-19. - JEOL JNM-ECZ400R NMR spectrometer equipped with a Royal HFX probe and an Auto Sample Changer for 64 samples. This three-channel system is capable of observing X nucleus resonance with simultaneous H-1 and F-19 decoupling. All NMR spectrometers are set up for routine high resolution solution state 1D and 2D NMR experiments.
