By Navin Saxena Research and Technology Pvt. Ltd.
Transdermal drug delivery system can offer advantages over oral or parenteral medication by delivery mode avoiding “first-pass” inactivation in the liver, elimination of gastrointestinal irritation, steady absorption of medication over long periods of time, reducing the frequency of dosing, self administration, improved patient compliance, and lowering the frequency of adverse effects through the avoidance of high serum drug peaks. Facility - Bulk manufacturing tanks - Casting, coating and drying machine - Cutting and pouching machine Technology With a specialized expertise in transdermal technology and drug delivery, NSRT has created various proprietary transdermal drug delivery systems: including our Platform Matrix Technology and Hydrogel Based Transdermal Patches. The PLATFORM MATRIX technology uses hydrophobic adhesives to deliver API (active pharmaceutical ingredient) through the skin. The matrix is capable of controlling the drug release for 24 hours. Almost all the drugs candidates of transdermal drug delivery system can be delivered through PLATFORM MATRIX Technology without addition of irritating permeation enhancers. Salient Features - Ideal for systemic drug delivery. - Well suited for formulation of various class of drugs - Offers controlled rate of drug release - Requires low loading of API with higher % of surface activity and better diffusion across the skin - Capable of incorporating API irrespective of physical form of either liquid, solid or semi-solid. - Suitable to deliver API systemically at a constant rate, and can be regulated with the use of rate control membrane for high-flux API. - The Matrix is thin, elegant and comfortable, and can be applicable for up to seven days. The HYDROGEL technology uses hydrophilic adhesives to create a skin-friendly formulation. Salient Features - Primarily used for topical administration. - Self-adhesive patch to be applied directly to the point of pain. - Prepared with jelly-like hydro-absorptive polymolecular compound. - The Hydrogel formulation contains high amount of water that provides a fresh cooling effect on the skin.
