Izon Science Ltd has announced the first major update to its Pulsoid nanoparticle measurement instrument, which the company launched in February 2026. New software takes the lower measurement limit down to 30 nm, and a new chip for larger particles extends the range up to 210 nm.
The software releases, Pulsoid Control Suite (PCS) 1.4.0 and Izon Data Suite 2 (IDS) 2.6.0, give a higher signal-to-noise ratio, so small particles stand out more clearly from background noise. The existing chip now measures particles as small as 30 nm with no change to the chip itself. The company said a 40 nm calibration standard (CPN40), previously at the edge of the range, now sits comfortably within it. IDS 2.6.0 also imports and exports data faster.
The new chip, P5T, measures 45 to 210 nm. It has a larger nanopore than P4T (previously known as SC80), making it easier and faster to run, and it still measures down to 45 nm. Together the two chips cover 30 to 210 nm. P5T chips are available to order through the Izon online store or a local Izon contact, and the company recommends starting with P5T unless particles are smaller than about 45 nm.
The Pulsoid measures particles one at a time as they pass through a fixed nanopore, a method Izon calls Nanopore Pulse Sensing (NPS). It provides size (volume and diameter), concentration and zeta potential data. The company said the update makes the instrument suited to extracellular vesicles, bacteriophages and lipid nanoparticles, and requires only 65 µL of sample.
In data from Professor Wojciech Chrzanowski's lab in Sydney, an unpurified bacteriophage sample gave a sharp peak at about 75 nm, separated from a smaller background population. "Pulsoid has been particularly valuable for analysing complex, non-spherical particle systems such as bacteriophages and hybrid conjugates with extracellular vesicles and nanoparticles," said Professor Wojciech Chrzanowski of Sydney Pharmacy School, The University of Sydney.
Source: Izon Science Ltd news
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