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Aphios Corp.
Consisting of biodegradable polymer nanospheres using PNS technology for anthrax vaccines Anthrax remains a significant bioterrorism threat to the United States and its allies. The current anthrax vaccine, BioThrax®, requires at least five injections at 0 and 4 weeks and then 6, 12 and 18 months fo
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Aphios Corp.
An orally bioavailable nanoformulation of betulinic acid, for melanoma APH-0201 is betulinic acid nanoparticles in biodegradable polymer nanospheres that will allow transport to the stomach and enhance oral bioavailability. Betulinic acid nanoparticles are first formed using PNP technology and the
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Aphios Corp.
An orally bioavailable nanoformulation of betulinic acid that works as an HIV maturation inhibitor APH-0202 is an oral nanoformulation containing betulinic acid. A pentacyclic triterpene, betulinic acid is a component of the bark of the white birch tree, Betula alba. Phospholipid nanosomes can be u
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Aphios Corp.
A non-toxic Vitamin D3 analog for hormone-refractory prostate cancer (HRPCA), designed to have increased antiproliferative effects while reducing systemic toxicity through increased specificity We are developing a nontoxic Vitamin D3 analog, APH-0701, which covalently links the bioactive hormone in
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Aphios Corp.
An oral nanoformulation of Δ9-THC for CINV, pain and cachexia in AIDS and cancer patients and Multiple Sclerosis. Δ9-THC – The Active Pharmaceutical Ingredient of Marijuana Tetrahydrocannabinol (Δ9-THC), the active pharmaceutical ingredient of marijuana (Cannabis sativa), is very hydrophobic and ox
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Aphios Corp.
A combination of Tdp1 inhibitors such as tetracycline and Top1 inhibitors such as topotecan or irinotecan, co-encapsulated in phospholipid nanosomes for camptothecin-resistant cancers Combination Therapy for Drug-Resistant Cancers Camptothecin is a potent anticancer agent that works by inhibiting t
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Aphios Corp.
A combination therapy consisting of PKC agonists with or without HDAC inhibitors, designed to reactivate latent HIV reservoirs so that HIV can be eliminated by antiviral therapy and eradicated from the body Although highly active antiretroviral therapy (HAART) is undoubtedly a lifesaving therapy fo
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Aphios Corp.
To enhance oral bioavailability for chronic chemotherapy or as a chemopreventive Poor Solubility and Associated Formulation and Bioavailability Difficulties Although paclitaxel is an effective anticancer drug, its solubility is low (~ 0.4 µg/mL), which limits its medical utility to intravenous app
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Aphios Corp.
APH-0912 is a combination of a Taxotere® prodrug and monoclonal antibody targeted to treat metastatic cancer The prodrug is a combination of a docetaxel molecule, the potent anticancer drug, and a sugar molecule to enhance solubility covalently linked to a tumor-specific antibody. This molecular co
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Aphios Corp.
An alpha (α)-secretase modulator for ameliorating Alzheimer’s Disease pathophysiology and cognitive impairment with neuroprotection Aphios is developing APH-1104, a more potent analog of Bryostatin-1, which is neuroprotective by α-secretase activation via novel PKC isoforms, down-regulation of pro-
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